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OBSCN-CASZ1 Fusion FISH Probe

The OBSCN-CASZ1 Fusion FISH Probe is used to confirm a fusion of the OBSCN and CASZ1 genes. The fusion of the OBSCN and CASZ1 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
OBSCN-CASZ1-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
OBSCN-CASZ1-20-RERE 20 (40 μL) 200 μL
OBSCN-CASZ1-20-REOR 20 (40 μL) 200 μL
OBSCN-CASZ1-20-REGO 20 (40 μL) 200 μL
OBSCN-CASZ1-20-REGR 20 (40 μL) 200 μL
OBSCN-CASZ1-20-REAQ 20 (40 μL) 200 μL
OBSCN-CASZ1-20-ORRE 20 (40 μL) 200 μL
OBSCN-CASZ1-20-OROR 20 (40 μL) 200 μL
OBSCN-CASZ1-20-ORGO 20 (40 μL) 200 μL
OBSCN-CASZ1-20-ORAQ 20 (40 μL) 200 μL
OBSCN-CASZ1-20-GORE 20 (40 μL) 200 μL
OBSCN-CASZ1-20-GOOR 20 (40 μL) 200 μL
OBSCN-CASZ1-20-GOGO 20 (40 μL) 200 μL
OBSCN-CASZ1-20-GOGR 20 (40 μL) 200 μL
OBSCN-CASZ1-20-GOAQ 20 (40 μL) 200 μL
OBSCN-CASZ1-20-GRRE 20 (40 μL) 200 μL
OBSCN-CASZ1-20-GROR 20 (40 μL) 200 μL
OBSCN-CASZ1-20-GRGO 20 (40 μL) 200 μL
OBSCN-CASZ1-20-GRGR 20 (40 μL) 200 μL
OBSCN-CASZ1-20-GRAQ 20 (40 μL) 200 μL
OBSCN-CASZ1-20-AQRE 20 (40 μL) 200 μL
OBSCN-CASZ1-20-AQOR 20 (40 μL) 200 μL
OBSCN-CASZ1-20-AQGO 20 (40 μL) 200 μL
OBSCN-CASZ1-20-AQGR 20 (40 μL) 200 μL
OBSCN-CASZ1-20-AQAQ 20 (40 μL) 200 μL

CASZ1 Gene Summary

The protein encoded by this gene is a zinc finger transcription factor. The encoded protein may function as a tumor suppressor, and single nucleotide polymorphisms in this gene are associated with blood pressure variation. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]

Gene Name: Castor Zinc Finger 1

Chromosome: CHR1: 10696665 -10856707

Locus: 1p36.22

OBSCN Gene Summary

The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Gene Name: Obscurin, Cytoskeletal Calmodulin And Titin-interacting RhoGEF

Chromosome: CHR1: 228395860 -228566575

Locus: 1q42.13

Gene Diseases

The OBSCN CASZ1 Fusion has been associated with the following diseases:

Disease Name
Head And Neck Squamous Cell Carcinoma 

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.