OLFM4-TOP2B Fusion FISH Probe
The OLFM4-TOP2B Fusion FISH Probe is used to confirm a fusion of the OLFM4 and TOP2B genes. The fusion of the OLFM4 and TOP2B genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| OLFM4-TOP2B-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| OLFM4-TOP2B-20-RERE | 20 (40 μL) | 200 μL |
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| OLFM4-TOP2B-20-REOR | 20 (40 μL) | 200 μL |
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| OLFM4-TOP2B-20-REGO | 20 (40 μL) | 200 μL |
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| OLFM4-TOP2B-20-REGR | 20 (40 μL) | 200 μL |
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| OLFM4-TOP2B-20-REAQ | 20 (40 μL) | 200 μL |
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| OLFM4-TOP2B-20-ORRE | 20 (40 μL) | 200 μL |
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| OLFM4-TOP2B-20-OROR | 20 (40 μL) | 200 μL |
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| OLFM4-TOP2B-20-ORGO | 20 (40 μL) | 200 μL |
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| OLFM4-TOP2B-20-ORAQ | 20 (40 μL) | 200 μL |
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| OLFM4-TOP2B-20-GORE | 20 (40 μL) | 200 μL |
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| OLFM4-TOP2B-20-GOOR | 20 (40 μL) | 200 μL |
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| OLFM4-TOP2B-20-GOGO | 20 (40 μL) | 200 μL |
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| OLFM4-TOP2B-20-GOGR | 20 (40 μL) | 200 μL |
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| OLFM4-TOP2B-20-GOAQ | 20 (40 μL) | 200 μL |
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| OLFM4-TOP2B-20-GRRE | 20 (40 μL) | 200 μL |
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| OLFM4-TOP2B-20-GROR | 20 (40 μL) | 200 μL |
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| OLFM4-TOP2B-20-GRGO | 20 (40 μL) | 200 μL |
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| OLFM4-TOP2B-20-GRGR | 20 (40 μL) | 200 μL |
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| OLFM4-TOP2B-20-GRAQ | 20 (40 μL) | 200 μL |
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| OLFM4-TOP2B-20-AQRE | 20 (40 μL) | 200 μL |
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| OLFM4-TOP2B-20-AQOR | 20 (40 μL) | 200 μL |
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| OLFM4-TOP2B-20-AQGO | 20 (40 μL) | 200 μL |
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| OLFM4-TOP2B-20-AQGR | 20 (40 μL) | 200 μL |
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| OLFM4-TOP2B-20-AQAQ | 20 (40 μL) | 200 μL |
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TOP2B Gene Summary
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, beta, is localized to chromosome 3 and the alpha form is localized to chromosome 17. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Gene Name: DNA Topoisomerase II Beta
Chromosome: CHR3: 25639474 -25705788
Locus: 3p24.2
OLFM4 Gene Summary
This gene was originally cloned from human myeloblasts and found to be selectively expressed in inflammed colonic epithelium. This gene encodes a member of the olfactomedin family. The encoded protein is an antiapoptotic factor that promotes tumor growth and is an extracellular matrix glycoprotein that facilitates cell adhesion. [provided by RefSeq, Mar 2011]
Gene Name: Olfactomedin 4
Chromosome: CHR13: 53602875 -53626196
Locus: 13q14.3
Gene Diseases
The OLFM4 TOP2B Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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