ABCC5-SPRR4 Fusion FISH Probe
The ABCC5-SPRR4 Fusion FISH Probe is used to confirm a fusion of the ABCC5 and SPRR4 genes. The fusion of the ABCC5 and SPRR4 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ABCC5-SPRR4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ABCC5-SPRR4-20-RERE | 20 (40 μL) | 200 μL |
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| ABCC5-SPRR4-20-REOR | 20 (40 μL) | 200 μL |
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| ABCC5-SPRR4-20-REGO | 20 (40 μL) | 200 μL |
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| ABCC5-SPRR4-20-REGR | 20 (40 μL) | 200 μL |
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| ABCC5-SPRR4-20-REAQ | 20 (40 μL) | 200 μL |
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| ABCC5-SPRR4-20-ORRE | 20 (40 μL) | 200 μL |
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| ABCC5-SPRR4-20-OROR | 20 (40 μL) | 200 μL |
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| ABCC5-SPRR4-20-ORGO | 20 (40 μL) | 200 μL |
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| ABCC5-SPRR4-20-ORAQ | 20 (40 μL) | 200 μL |
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| ABCC5-SPRR4-20-GORE | 20 (40 μL) | 200 μL |
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| ABCC5-SPRR4-20-GOOR | 20 (40 μL) | 200 μL |
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| ABCC5-SPRR4-20-GOGO | 20 (40 μL) | 200 μL |
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| ABCC5-SPRR4-20-GOGR | 20 (40 μL) | 200 μL |
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| ABCC5-SPRR4-20-GOAQ | 20 (40 μL) | 200 μL |
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| ABCC5-SPRR4-20-GRRE | 20 (40 μL) | 200 μL |
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| ABCC5-SPRR4-20-GROR | 20 (40 μL) | 200 μL |
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| ABCC5-SPRR4-20-GRGO | 20 (40 μL) | 200 μL |
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| ABCC5-SPRR4-20-GRGR | 20 (40 μL) | 200 μL |
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| ABCC5-SPRR4-20-GRAQ | 20 (40 μL) | 200 μL |
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| ABCC5-SPRR4-20-AQRE | 20 (40 μL) | 200 μL |
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| ABCC5-SPRR4-20-AQOR | 20 (40 μL) | 200 μL |
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| ABCC5-SPRR4-20-AQGO | 20 (40 μL) | 200 μL |
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| ABCC5-SPRR4-20-AQGR | 20 (40 μL) | 200 μL |
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| ABCC5-SPRR4-20-AQAQ | 20 (40 μL) | 200 μL |
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ABCC5 Gene Summary
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Gene Name: ATP Binding Cassette Subfamily C Member 5
Chromosome: CHR3: 183637723 -183735727
Locus: 3q27.1
SPRR4 Gene Summary
The Small Proline Rich Protein 4 (SPRR4) gene is located on chr1 :152943127-152945069 at 1q21.3.
Gene Name: Small Proline Rich Protein 4
Chromosome: CHR1: 152943127 -152945069
Locus: 1q21.3
Gene Diseases
The ABCC5 SPRR4 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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