ACTB-HLA-DQB1 Fusion FISH Probe
The ACTB-HLA-DQB1 Fusion FISH Probe is used to confirm a fusion of the ACTB and HLA-DQB1 genes. The fusion of the ACTB and HLA-DQB1 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ACTB-HLA-DQB1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ACTB-HLA-DQB1-20-RERE | 20 (40 μL) | 200 μL |
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| ACTB-HLA-DQB1-20-REOR | 20 (40 μL) | 200 μL |
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| ACTB-HLA-DQB1-20-REGO | 20 (40 μL) | 200 μL |
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| ACTB-HLA-DQB1-20-REGR | 20 (40 μL) | 200 μL |
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| ACTB-HLA-DQB1-20-REAQ | 20 (40 μL) | 200 μL |
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| ACTB-HLA-DQB1-20-ORRE | 20 (40 μL) | 200 μL |
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| ACTB-HLA-DQB1-20-OROR | 20 (40 μL) | 200 μL |
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| ACTB-HLA-DQB1-20-ORGO | 20 (40 μL) | 200 μL |
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| ACTB-HLA-DQB1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ACTB-HLA-DQB1-20-GORE | 20 (40 μL) | 200 μL |
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| ACTB-HLA-DQB1-20-GOOR | 20 (40 μL) | 200 μL |
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| ACTB-HLA-DQB1-20-GOGO | 20 (40 μL) | 200 μL |
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| ACTB-HLA-DQB1-20-GOGR | 20 (40 μL) | 200 μL |
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| ACTB-HLA-DQB1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ACTB-HLA-DQB1-20-GRRE | 20 (40 μL) | 200 μL |
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| ACTB-HLA-DQB1-20-GROR | 20 (40 μL) | 200 μL |
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| ACTB-HLA-DQB1-20-GRGO | 20 (40 μL) | 200 μL |
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| ACTB-HLA-DQB1-20-GRGR | 20 (40 μL) | 200 μL |
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| ACTB-HLA-DQB1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ACTB-HLA-DQB1-20-AQRE | 20 (40 μL) | 200 μL |
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| ACTB-HLA-DQB1-20-AQOR | 20 (40 μL) | 200 μL |
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| ACTB-HLA-DQB1-20-AQGO | 20 (40 μL) | 200 μL |
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| ACTB-HLA-DQB1-20-AQGR | 20 (40 μL) | 200 μL |
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| ACTB-HLA-DQB1-20-AQAQ | 20 (40 μL) | 200 μL |
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ACTB Gene Summary
This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins that are ubiquitously expressed. Mutations in this gene cause Baraitser-Winter syndrome 1, which is characterized by intellectual disability with a distinctive facial appearance in human patients. Numerous pseudogenes of this gene have been identified throughout the human genome. [provided by RefSeq, Aug 2017]
Gene Name: Actin Beta
Chromosome: CHR7: 5566778 -5570232
Locus: 7p22.1
HLA-DQB1 Gene Summary
HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Gene Name: Major Histocompatibility Complex, Class II, DQ Beta 1
Chromosome: CHR6_cox_hap2: 4072510 -4080111
Locus: 6p21.32
Gene Diseases
The ACTB HLA-DQB1 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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