ACTB-YWHAE Fusion FISH Probe
The ACTB-YWHAE Fusion FISH Probe is used to confirm a fusion of the ACTB and YWHAE genes. The fusion of the ACTB and YWHAE genes has been associated with Kidney Renal Papillary Cell Carcinoma, and Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ACTB-YWHAE-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ACTB-YWHAE-20-RERE | 20 (40 μL) | 200 μL |
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| ACTB-YWHAE-20-REOR | 20 (40 μL) | 200 μL |
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| ACTB-YWHAE-20-REGO | 20 (40 μL) | 200 μL |
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| ACTB-YWHAE-20-REGR | 20 (40 μL) | 200 μL |
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| ACTB-YWHAE-20-REAQ | 20 (40 μL) | 200 μL |
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| ACTB-YWHAE-20-ORRE | 20 (40 μL) | 200 μL |
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| ACTB-YWHAE-20-OROR | 20 (40 μL) | 200 μL |
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| ACTB-YWHAE-20-ORGO | 20 (40 μL) | 200 μL |
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| ACTB-YWHAE-20-ORAQ | 20 (40 μL) | 200 μL |
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| ACTB-YWHAE-20-GORE | 20 (40 μL) | 200 μL |
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| ACTB-YWHAE-20-GOOR | 20 (40 μL) | 200 μL |
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| ACTB-YWHAE-20-GOGO | 20 (40 μL) | 200 μL |
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| ACTB-YWHAE-20-GOGR | 20 (40 μL) | 200 μL |
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| ACTB-YWHAE-20-GOAQ | 20 (40 μL) | 200 μL |
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| ACTB-YWHAE-20-GRRE | 20 (40 μL) | 200 μL |
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| ACTB-YWHAE-20-GROR | 20 (40 μL) | 200 μL |
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| ACTB-YWHAE-20-GRGO | 20 (40 μL) | 200 μL |
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| ACTB-YWHAE-20-GRGR | 20 (40 μL) | 200 μL |
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| ACTB-YWHAE-20-GRAQ | 20 (40 μL) | 200 μL |
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| ACTB-YWHAE-20-AQRE | 20 (40 μL) | 200 μL |
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| ACTB-YWHAE-20-AQOR | 20 (40 μL) | 200 μL |
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| ACTB-YWHAE-20-AQGO | 20 (40 μL) | 200 μL |
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| ACTB-YWHAE-20-AQGR | 20 (40 μL) | 200 μL |
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| ACTB-YWHAE-20-AQAQ | 20 (40 μL) | 200 μL |
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ACTB Gene Summary
This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins that are ubiquitously expressed. Mutations in this gene cause Baraitser-Winter syndrome 1, which is characterized by intellectual disability with a distinctive facial appearance in human patients. Numerous pseudogenes of this gene have been identified throughout the human genome. [provided by RefSeq, Aug 2017]
Gene Name: Actin Beta
Chromosome: CHR7: 5566778 -5570232
Locus: 7p22.1
YWHAE Gene Summary
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]
Gene Name: Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase Activation Protein Epsilon
Chromosome: CHR17: 1247833 -1303556
Locus: 17p13.3
Gene Diseases
The ACTB YWHAE Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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