ACTG1-CLCN3 Fusion FISH Probe
The ACTG1-CLCN3 Fusion FISH Probe is used to confirm a fusion of the ACTG1 and CLCN3 genes. The fusion of the ACTG1 and CLCN3 genes has been associated with Kidney Renal Papillary Cell Carcinoma, and Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ACTG1-CLCN3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ACTG1-CLCN3-20-RERE | 20 (40 μL) | 200 μL |
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| ACTG1-CLCN3-20-REOR | 20 (40 μL) | 200 μL |
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| ACTG1-CLCN3-20-REGO | 20 (40 μL) | 200 μL |
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| ACTG1-CLCN3-20-REGR | 20 (40 μL) | 200 μL |
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| ACTG1-CLCN3-20-REAQ | 20 (40 μL) | 200 μL |
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| ACTG1-CLCN3-20-ORRE | 20 (40 μL) | 200 μL |
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| ACTG1-CLCN3-20-OROR | 20 (40 μL) | 200 μL |
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| ACTG1-CLCN3-20-ORGO | 20 (40 μL) | 200 μL |
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| ACTG1-CLCN3-20-ORAQ | 20 (40 μL) | 200 μL |
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| ACTG1-CLCN3-20-GORE | 20 (40 μL) | 200 μL |
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| ACTG1-CLCN3-20-GOOR | 20 (40 μL) | 200 μL |
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| ACTG1-CLCN3-20-GOGO | 20 (40 μL) | 200 μL |
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| ACTG1-CLCN3-20-GOGR | 20 (40 μL) | 200 μL |
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| ACTG1-CLCN3-20-GOAQ | 20 (40 μL) | 200 μL |
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| ACTG1-CLCN3-20-GRRE | 20 (40 μL) | 200 μL |
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| ACTG1-CLCN3-20-GROR | 20 (40 μL) | 200 μL |
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| ACTG1-CLCN3-20-GRGO | 20 (40 μL) | 200 μL |
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| ACTG1-CLCN3-20-GRGR | 20 (40 μL) | 200 μL |
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| ACTG1-CLCN3-20-GRAQ | 20 (40 μL) | 200 μL |
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| ACTG1-CLCN3-20-AQRE | 20 (40 μL) | 200 μL |
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| ACTG1-CLCN3-20-AQOR | 20 (40 μL) | 200 μL |
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| ACTG1-CLCN3-20-AQGO | 20 (40 μL) | 200 μL |
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| ACTG1-CLCN3-20-AQGR | 20 (40 μL) | 200 μL |
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| ACTG1-CLCN3-20-AQAQ | 20 (40 μL) | 200 μL |
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ACTG1 Gene Summary
Actins are highly conserved proteins that are involved in various types of cell motility and in maintenance of the cytoskeleton. Three main groups of actin isoforms have been identified in vertebrate animals: alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. Actin gamma 1, encoded by this gene, is a cytoplasmic actin found in all cell types. Mutations in this gene are associated with DFNA20/26, a subtype of autosomal dominant non-syndromic sensorineural progressive hearing loss and also with Baraitser-Winter syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]
Gene Name: Actin Gamma 1
Chromosome: CHR17: 79476996 -79479892
Locus: 17q25.3
CLCN3 Gene Summary
This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Name: Chloride Voltage-gated Channel 3
Chromosome: CHR4: 170541671 -170644338
Locus: 4q33
Gene Diseases
The ACTG1 CLCN3 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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