ACTG1-CXCR5 Fusion FISH Probe
The ACTG1-CXCR5 Fusion FISH Probe is used to confirm a fusion of the ACTG1 and CXCR5 genes. The fusion of the ACTG1 and CXCR5 genes has been associated with Lymphoid Neoplasm Diffuse Large B-cell Lymphoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ACTG1-CXCR5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ACTG1-CXCR5-20-RERE | 20 (40 μL) | 200 μL |
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| ACTG1-CXCR5-20-REOR | 20 (40 μL) | 200 μL |
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| ACTG1-CXCR5-20-REGO | 20 (40 μL) | 200 μL |
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| ACTG1-CXCR5-20-REGR | 20 (40 μL) | 200 μL |
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| ACTG1-CXCR5-20-REAQ | 20 (40 μL) | 200 μL |
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| ACTG1-CXCR5-20-ORRE | 20 (40 μL) | 200 μL |
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| ACTG1-CXCR5-20-OROR | 20 (40 μL) | 200 μL |
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| ACTG1-CXCR5-20-ORGO | 20 (40 μL) | 200 μL |
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| ACTG1-CXCR5-20-ORAQ | 20 (40 μL) | 200 μL |
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| ACTG1-CXCR5-20-GORE | 20 (40 μL) | 200 μL |
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| ACTG1-CXCR5-20-GOOR | 20 (40 μL) | 200 μL |
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| ACTG1-CXCR5-20-GOGO | 20 (40 μL) | 200 μL |
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| ACTG1-CXCR5-20-GOGR | 20 (40 μL) | 200 μL |
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| ACTG1-CXCR5-20-GOAQ | 20 (40 μL) | 200 μL |
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| ACTG1-CXCR5-20-GRRE | 20 (40 μL) | 200 μL |
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| ACTG1-CXCR5-20-GROR | 20 (40 μL) | 200 μL |
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| ACTG1-CXCR5-20-GRGO | 20 (40 μL) | 200 μL |
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| ACTG1-CXCR5-20-GRGR | 20 (40 μL) | 200 μL |
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| ACTG1-CXCR5-20-GRAQ | 20 (40 μL) | 200 μL |
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| ACTG1-CXCR5-20-AQRE | 20 (40 μL) | 200 μL |
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| ACTG1-CXCR5-20-AQOR | 20 (40 μL) | 200 μL |
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| ACTG1-CXCR5-20-AQGO | 20 (40 μL) | 200 μL |
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| ACTG1-CXCR5-20-AQGR | 20 (40 μL) | 200 μL |
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| ACTG1-CXCR5-20-AQAQ | 20 (40 μL) | 200 μL |
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ACTG1 Gene Summary
Actins are highly conserved proteins that are involved in various types of cell motility and in maintenance of the cytoskeleton. Three main groups of actin isoforms have been identified in vertebrate animals: alpha, beta, and gamma. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. Actin gamma 1, encoded by this gene, is a cytoplasmic actin found in all cell types. Mutations in this gene are associated with DFNA20/26, a subtype of autosomal dominant non-syndromic sensorineural progressive hearing loss and also with Baraitser-Winter syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]
Gene Name: Actin Gamma 1
Chromosome: CHR17: 79476996 -79479892
Locus: 17q25.3
CXCR5 Gene Summary
This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC), and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Gene Name: C-X-C Motif Chemokine Receptor 5
Chromosome: CHR11: 118754474 -118766980
Locus: 11q23.3
Gene Diseases
The ACTG1 CXCR5 Fusion has been associated with the following diseases:
| Disease Name |
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| Lymphoid Neoplasm Diffuse Large B-cell Lymphoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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