ACTG2-ALK Fusion FISH Probe
The ACTG2-ALK Fusion FISH Probe is used to confirm a fusion of the ACTG2 and ALK genes. The fusion of the ACTG2 and ALK genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ACTG2-ALK-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ACTG2-ALK-20-RERE | 20 (40 μL) | 200 μL |
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| ACTG2-ALK-20-REOR | 20 (40 μL) | 200 μL |
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| ACTG2-ALK-20-REGO | 20 (40 μL) | 200 μL |
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| ACTG2-ALK-20-REGR | 20 (40 μL) | 200 μL |
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| ACTG2-ALK-20-REAQ | 20 (40 μL) | 200 μL |
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| ACTG2-ALK-20-ORRE | 20 (40 μL) | 200 μL |
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| ACTG2-ALK-20-OROR | 20 (40 μL) | 200 μL |
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| ACTG2-ALK-20-ORGO | 20 (40 μL) | 200 μL |
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| ACTG2-ALK-20-ORAQ | 20 (40 μL) | 200 μL |
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| ACTG2-ALK-20-GORE | 20 (40 μL) | 200 μL |
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| ACTG2-ALK-20-GOOR | 20 (40 μL) | 200 μL |
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| ACTG2-ALK-20-GOGO | 20 (40 μL) | 200 μL |
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| ACTG2-ALK-20-GOGR | 20 (40 μL) | 200 μL |
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| ACTG2-ALK-20-GOAQ | 20 (40 μL) | 200 μL |
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| ACTG2-ALK-20-GRRE | 20 (40 μL) | 200 μL |
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| ACTG2-ALK-20-GROR | 20 (40 μL) | 200 μL |
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| ACTG2-ALK-20-GRGO | 20 (40 μL) | 200 μL |
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| ACTG2-ALK-20-GRGR | 20 (40 μL) | 200 μL |
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| ACTG2-ALK-20-GRAQ | 20 (40 μL) | 200 μL |
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| ACTG2-ALK-20-AQRE | 20 (40 μL) | 200 μL |
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| ACTG2-ALK-20-AQOR | 20 (40 μL) | 200 μL |
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| ACTG2-ALK-20-AQGO | 20 (40 μL) | 200 μL |
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| ACTG2-ALK-20-AQGR | 20 (40 μL) | 200 μL |
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| ACTG2-ALK-20-AQAQ | 20 (40 μL) | 200 μL |
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ACTG2 Gene Summary
Actins are highly conserved proteins that are involved in various types of cell motility and in the maintenance of the cytoskeleton. Three types of actins, alpha, beta and gamma, have been identified in vertebrates. Alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton and as mediators of internal cell motility. This gene encodes actin gamma 2; a smooth muscle actin found in enteric tissues. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Based on similarity to peptide cleavage of related actins, the mature protein of this gene is formed by removal of two N-terminal peptides.[provided by RefSeq, Dec 2010]
Gene Name: Actin, Gamma 2, Smooth Muscle, Enteric
Chromosome: CHR2: 74120092 -74146780
Locus: 2p13.1
ALK Gene Summary
This gene encodes a receptor tyrosine kinase, which belongs to the insulin receptor superfamily. This protein comprises an extracellular domain, an hydrophobic stretch corresponding to a single pass transmembrane region, and an intracellular kinase domain. It plays an important role in the development of the brain and exerts its effects on specific neurons in the nervous system. This gene has been found to be rearranged, mutated, or amplified in a series of tumours including anaplastic large cell lymphomas, neuroblastoma, and non-small cell lung cancer. The chromosomal rearrangements are the most common genetic alterations in this gene, which result in creation of multiple fusion genes in tumourigenesis, including ALK (chromosome 2)/EML4 (chromosome 2), ALK/RANBP2 (chromosome 2), ALK/ATIC (chromosome 2), ALK/TFG (chromosome 3), ALK/NPM1 (chromosome 5), ALK/SQSTM1 (chromosome 5), ALK/KIF5B (chromosome 10), ALK/CLTC (chromosome 17), ALK/TPM4 (chromosome 19), and ALK/MSN (chromosome X).[provided by RefSeq, Jan 2011]
Gene Name: ALK Receptor Tyrosine Kinase
Chromosome: CHR2: 29415639 -30144477
Locus: 2p23.2-p23.1
Gene Diseases
The ACTG2 ALK Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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