ACTN1-SCGN Fusion FISH Probe
The ACTN1-SCGN Fusion FISH Probe is used to confirm a fusion of the ACTN1 and SCGN genes. The fusion of the ACTN1 and SCGN genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ACTN1-SCGN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ACTN1-SCGN-20-RERE | 20 (40 μL) | 200 μL |
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| ACTN1-SCGN-20-REOR | 20 (40 μL) | 200 μL |
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| ACTN1-SCGN-20-REGO | 20 (40 μL) | 200 μL |
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| ACTN1-SCGN-20-REGR | 20 (40 μL) | 200 μL |
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| ACTN1-SCGN-20-REAQ | 20 (40 μL) | 200 μL |
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| ACTN1-SCGN-20-ORRE | 20 (40 μL) | 200 μL |
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| ACTN1-SCGN-20-OROR | 20 (40 μL) | 200 μL |
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| ACTN1-SCGN-20-ORGO | 20 (40 μL) | 200 μL |
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| ACTN1-SCGN-20-ORAQ | 20 (40 μL) | 200 μL |
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| ACTN1-SCGN-20-GORE | 20 (40 μL) | 200 μL |
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| ACTN1-SCGN-20-GOOR | 20 (40 μL) | 200 μL |
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| ACTN1-SCGN-20-GOGO | 20 (40 μL) | 200 μL |
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| ACTN1-SCGN-20-GOGR | 20 (40 μL) | 200 μL |
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| ACTN1-SCGN-20-GOAQ | 20 (40 μL) | 200 μL |
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| ACTN1-SCGN-20-GRRE | 20 (40 μL) | 200 μL |
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| ACTN1-SCGN-20-GROR | 20 (40 μL) | 200 μL |
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| ACTN1-SCGN-20-GRGO | 20 (40 μL) | 200 μL |
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| ACTN1-SCGN-20-GRGR | 20 (40 μL) | 200 μL |
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| ACTN1-SCGN-20-GRAQ | 20 (40 μL) | 200 μL |
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| ACTN1-SCGN-20-AQRE | 20 (40 μL) | 200 μL |
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| ACTN1-SCGN-20-AQOR | 20 (40 μL) | 200 μL |
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| ACTN1-SCGN-20-AQGO | 20 (40 μL) | 200 μL |
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| ACTN1-SCGN-20-AQGR | 20 (40 μL) | 200 μL |
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| ACTN1-SCGN-20-AQAQ | 20 (40 μL) | 200 μL |
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ACTN1 Gene Summary
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, cytoskeletal, alpha actinin isoform and maps to the same site as the structurally similar erythroid beta spectrin gene. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Actinin Alpha 1
Chromosome: CHR14: 69340839 -69446083
Locus: 14q22-q24
SCGN Gene Summary
The encoded protein is a secreted calcium-binding protein which is found in the cytoplasm. It is related to calbindin D-28K and calretinin. This protein is thought to be involved in KCL-stimulated calcium flux and cell proliferation. [provided by RefSeq, Jul 2008]
Gene Name: Secretagogin, EF-hand Calcium Binding Protein
Chromosome: CHR6: 25652428 -25702008
Locus: 6p22.2
Gene Diseases
The ACTN1 SCGN Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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