ACTN2-CHRM3 Fusion FISH Probe
The ACTN2-CHRM3 Fusion FISH Probe is used to confirm a fusion of the ACTN2 and CHRM3 genes. The fusion of the ACTN2 and CHRM3 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ACTN2-CHRM3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ACTN2-CHRM3-20-RERE | 20 (40 μL) | 200 μL |
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| ACTN2-CHRM3-20-REOR | 20 (40 μL) | 200 μL |
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| ACTN2-CHRM3-20-REGO | 20 (40 μL) | 200 μL |
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| ACTN2-CHRM3-20-REGR | 20 (40 μL) | 200 μL |
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| ACTN2-CHRM3-20-REAQ | 20 (40 μL) | 200 μL |
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| ACTN2-CHRM3-20-ORRE | 20 (40 μL) | 200 μL |
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| ACTN2-CHRM3-20-OROR | 20 (40 μL) | 200 μL |
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| ACTN2-CHRM3-20-ORGO | 20 (40 μL) | 200 μL |
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| ACTN2-CHRM3-20-ORAQ | 20 (40 μL) | 200 μL |
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| ACTN2-CHRM3-20-GORE | 20 (40 μL) | 200 μL |
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| ACTN2-CHRM3-20-GOOR | 20 (40 μL) | 200 μL |
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| ACTN2-CHRM3-20-GOGO | 20 (40 μL) | 200 μL |
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| ACTN2-CHRM3-20-GOGR | 20 (40 μL) | 200 μL |
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| ACTN2-CHRM3-20-GOAQ | 20 (40 μL) | 200 μL |
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| ACTN2-CHRM3-20-GRRE | 20 (40 μL) | 200 μL |
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| ACTN2-CHRM3-20-GROR | 20 (40 μL) | 200 μL |
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| ACTN2-CHRM3-20-GRGO | 20 (40 μL) | 200 μL |
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| ACTN2-CHRM3-20-GRGR | 20 (40 μL) | 200 μL |
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| ACTN2-CHRM3-20-GRAQ | 20 (40 μL) | 200 μL |
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| ACTN2-CHRM3-20-AQRE | 20 (40 μL) | 200 μL |
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| ACTN2-CHRM3-20-AQOR | 20 (40 μL) | 200 μL |
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| ACTN2-CHRM3-20-AQGO | 20 (40 μL) | 200 μL |
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| ACTN2-CHRM3-20-AQGR | 20 (40 μL) | 200 μL |
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| ACTN2-CHRM3-20-AQAQ | 20 (40 μL) | 200 μL |
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ACTN2 Gene Summary
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2013]
Gene Name: Actinin Alpha 2
Chromosome: CHR1: 236849769 -236927558
Locus: 1q43
CHRM3 Gene Summary
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 3 controls smooth muscle contraction and its stimulation causes secretion of glandular tissue. Alternative promoter use and alternative splicing results in multiple transcript variants that have different tissue specificities. [provided by RefSeq, Dec 2016]
Gene Name: Cholinergic Receptor Muscarinic 3
Chromosome: CHR1: 239792372 -240072717
Locus: 1q43
Gene Diseases
The ACTN2 CHRM3 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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