ACTN4-MGST2 Fusion FISH Probe
The ACTN4-MGST2 Fusion FISH Probe is used to confirm a fusion of the ACTN4 and MGST2 genes. The fusion of the ACTN4 and MGST2 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ACTN4-MGST2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ACTN4-MGST2-20-RERE | 20 (40 μL) | 200 μL |
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| ACTN4-MGST2-20-REOR | 20 (40 μL) | 200 μL |
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| ACTN4-MGST2-20-REGO | 20 (40 μL) | 200 μL |
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| ACTN4-MGST2-20-REGR | 20 (40 μL) | 200 μL |
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| ACTN4-MGST2-20-REAQ | 20 (40 μL) | 200 μL |
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| ACTN4-MGST2-20-ORRE | 20 (40 μL) | 200 μL |
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| ACTN4-MGST2-20-OROR | 20 (40 μL) | 200 μL |
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| ACTN4-MGST2-20-ORGO | 20 (40 μL) | 200 μL |
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| ACTN4-MGST2-20-ORAQ | 20 (40 μL) | 200 μL |
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| ACTN4-MGST2-20-GORE | 20 (40 μL) | 200 μL |
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| ACTN4-MGST2-20-GOOR | 20 (40 μL) | 200 μL |
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| ACTN4-MGST2-20-GOGO | 20 (40 μL) | 200 μL |
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| ACTN4-MGST2-20-GOGR | 20 (40 μL) | 200 μL |
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| ACTN4-MGST2-20-GOAQ | 20 (40 μL) | 200 μL |
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| ACTN4-MGST2-20-GRRE | 20 (40 μL) | 200 μL |
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| ACTN4-MGST2-20-GROR | 20 (40 μL) | 200 μL |
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| ACTN4-MGST2-20-GRGO | 20 (40 μL) | 200 μL |
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| ACTN4-MGST2-20-GRGR | 20 (40 μL) | 200 μL |
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| ACTN4-MGST2-20-GRAQ | 20 (40 μL) | 200 μL |
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| ACTN4-MGST2-20-AQRE | 20 (40 μL) | 200 μL |
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| ACTN4-MGST2-20-AQOR | 20 (40 μL) | 200 μL |
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| ACTN4-MGST2-20-AQGO | 20 (40 μL) | 200 μL |
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| ACTN4-MGST2-20-AQGR | 20 (40 μL) | 200 μL |
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| ACTN4-MGST2-20-AQAQ | 20 (40 μL) | 200 μL |
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ACTN4 Gene Summary
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008]
Gene Name: Actinin Alpha 4
Chromosome: CHR19: 39138266 -39221171
Locus: 19q13.2
MGST2 Gene Summary
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes a protein which catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Feb 2011]
Gene Name: Microsomal Glutathione S-transferase 2
Chromosome: CHR4: 140586921 -140661899
Locus: 4q31.1
Gene Diseases
The ACTN4 MGST2 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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