ACTN4-TXNDC12 Fusion FISH Probe
The ACTN4-TXNDC12 Fusion FISH Probe is used to confirm a fusion of the ACTN4 and TXNDC12 genes. The fusion of the ACTN4 and TXNDC12 genes has been associated with Glioblastoma Multiforme. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ACTN4-TXNDC12-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ACTN4-TXNDC12-20-RERE | 20 (40 μL) | 200 μL |
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| ACTN4-TXNDC12-20-REOR | 20 (40 μL) | 200 μL |
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| ACTN4-TXNDC12-20-REGO | 20 (40 μL) | 200 μL |
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| ACTN4-TXNDC12-20-REGR | 20 (40 μL) | 200 μL |
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| ACTN4-TXNDC12-20-REAQ | 20 (40 μL) | 200 μL |
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| ACTN4-TXNDC12-20-ORRE | 20 (40 μL) | 200 μL |
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| ACTN4-TXNDC12-20-OROR | 20 (40 μL) | 200 μL |
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| ACTN4-TXNDC12-20-ORGO | 20 (40 μL) | 200 μL |
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| ACTN4-TXNDC12-20-ORAQ | 20 (40 μL) | 200 μL |
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| ACTN4-TXNDC12-20-GORE | 20 (40 μL) | 200 μL |
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| ACTN4-TXNDC12-20-GOOR | 20 (40 μL) | 200 μL |
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| ACTN4-TXNDC12-20-GOGO | 20 (40 μL) | 200 μL |
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| ACTN4-TXNDC12-20-GOGR | 20 (40 μL) | 200 μL |
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| ACTN4-TXNDC12-20-GOAQ | 20 (40 μL) | 200 μL |
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| ACTN4-TXNDC12-20-GRRE | 20 (40 μL) | 200 μL |
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| ACTN4-TXNDC12-20-GROR | 20 (40 μL) | 200 μL |
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| ACTN4-TXNDC12-20-GRGO | 20 (40 μL) | 200 μL |
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| ACTN4-TXNDC12-20-GRGR | 20 (40 μL) | 200 μL |
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| ACTN4-TXNDC12-20-GRAQ | 20 (40 μL) | 200 μL |
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| ACTN4-TXNDC12-20-AQRE | 20 (40 μL) | 200 μL |
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| ACTN4-TXNDC12-20-AQOR | 20 (40 μL) | 200 μL |
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| ACTN4-TXNDC12-20-AQGO | 20 (40 μL) | 200 μL |
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| ACTN4-TXNDC12-20-AQGR | 20 (40 μL) | 200 μL |
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| ACTN4-TXNDC12-20-AQAQ | 20 (40 μL) | 200 μL |
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ACTN4 Gene Summary
Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008]
Gene Name: Actinin Alpha 4
Chromosome: CHR19: 39138266 -39221171
Locus: 19q13.2
TXNDC12 Gene Summary
This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. This protein localizes to the endoplasmic reticulum and has a single atypical active motif. The encoded protein is mainly involved in catalyzing native disulfide bond formation and displays activity similar to protein-disulfide isomerases. This protein may play a role in defense against endoplasmic reticulum stress. Alternate splicing results in both coding and non-coding variants. [provided by RefSeq, Mar 2012]
Gene Name: Thioredoxin Domain Containing 12
Chromosome: CHR1: 52485803 -52521047
Locus: 1p32.3
Gene Diseases
The ACTN4 TXNDC12 Fusion has been associated with the following diseases:
| Disease Name |
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| Glioblastoma Multiforme |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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