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ACTN4-YIF1B Fusion FISH Probe

The ACTN4-YIF1B Fusion FISH Probe is used to confirm a fusion of the ACTN4 and YIF1B genes. The fusion of the ACTN4 and YIF1B genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
ACTN4-YIF1B-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
ACTN4-YIF1B-20-RERE 20 (40 μL) 200 μL
ACTN4-YIF1B-20-REOR 20 (40 μL) 200 μL
ACTN4-YIF1B-20-REGO 20 (40 μL) 200 μL
ACTN4-YIF1B-20-REGR 20 (40 μL) 200 μL
ACTN4-YIF1B-20-REAQ 20 (40 μL) 200 μL
ACTN4-YIF1B-20-ORRE 20 (40 μL) 200 μL
ACTN4-YIF1B-20-OROR 20 (40 μL) 200 μL
ACTN4-YIF1B-20-ORGO 20 (40 μL) 200 μL
ACTN4-YIF1B-20-ORAQ 20 (40 μL) 200 μL
ACTN4-YIF1B-20-GORE 20 (40 μL) 200 μL
ACTN4-YIF1B-20-GOOR 20 (40 μL) 200 μL
ACTN4-YIF1B-20-GOGO 20 (40 μL) 200 μL
ACTN4-YIF1B-20-GOGR 20 (40 μL) 200 μL
ACTN4-YIF1B-20-GOAQ 20 (40 μL) 200 μL
ACTN4-YIF1B-20-GRRE 20 (40 μL) 200 μL
ACTN4-YIF1B-20-GROR 20 (40 μL) 200 μL
ACTN4-YIF1B-20-GRGO 20 (40 μL) 200 μL
ACTN4-YIF1B-20-GRGR 20 (40 μL) 200 μL
ACTN4-YIF1B-20-GRAQ 20 (40 μL) 200 μL
ACTN4-YIF1B-20-AQRE 20 (40 μL) 200 μL
ACTN4-YIF1B-20-AQOR 20 (40 μL) 200 μL
ACTN4-YIF1B-20-AQGO 20 (40 μL) 200 μL
ACTN4-YIF1B-20-AQGR 20 (40 μL) 200 μL
ACTN4-YIF1B-20-AQAQ 20 (40 μL) 200 μL

ACTN4 Gene Summary

Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In nonmuscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a nonmuscle, alpha actinin isoform which is concentrated in the cytoplasm, and thought to be involved in metastatic processes. Mutations in this gene have been associated with focal and segmental glomerulosclerosis. [provided by RefSeq, Jul 2008]

Gene Name: Actinin Alpha 4

Chromosome: CHR19: 39138266 -39221171

Locus: 19q13.2

YIF1B Gene Summary

The Yip1 Interacting Factor Homolog B, Membrane Trafficking Protein (YIF1B) gene is located on chr19 :38794199-38806606 at 19q13.2.

Gene Name: Yip1 Interacting Factor Homolog B, Membrane Trafficking Protein

Chromosome: CHR19: 38794199 -38806606

Locus: 19q13.2

Gene Diseases

The ACTN4 YIF1B Fusion has been associated with the following diseases:

Disease Name
Lung Adenocarcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.