ACTR1A-ARMC4 Fusion FISH Probe
The ACTR1A-ARMC4 Fusion FISH Probe is used to confirm a fusion of the ACTR1A and ARMC4 genes. The fusion of the ACTR1A and ARMC4 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ACTR1A-ARMC4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ACTR1A-ARMC4-20-RERE | 20 (40 μL) | 200 μL |
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| ACTR1A-ARMC4-20-REOR | 20 (40 μL) | 200 μL |
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| ACTR1A-ARMC4-20-REGO | 20 (40 μL) | 200 μL |
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| ACTR1A-ARMC4-20-REGR | 20 (40 μL) | 200 μL |
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| ACTR1A-ARMC4-20-REAQ | 20 (40 μL) | 200 μL |
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| ACTR1A-ARMC4-20-ORRE | 20 (40 μL) | 200 μL |
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| ACTR1A-ARMC4-20-OROR | 20 (40 μL) | 200 μL |
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| ACTR1A-ARMC4-20-ORGO | 20 (40 μL) | 200 μL |
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| ACTR1A-ARMC4-20-ORAQ | 20 (40 μL) | 200 μL |
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| ACTR1A-ARMC4-20-GORE | 20 (40 μL) | 200 μL |
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| ACTR1A-ARMC4-20-GOOR | 20 (40 μL) | 200 μL |
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| ACTR1A-ARMC4-20-GOGO | 20 (40 μL) | 200 μL |
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| ACTR1A-ARMC4-20-GOGR | 20 (40 μL) | 200 μL |
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| ACTR1A-ARMC4-20-GOAQ | 20 (40 μL) | 200 μL |
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| ACTR1A-ARMC4-20-GRRE | 20 (40 μL) | 200 μL |
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| ACTR1A-ARMC4-20-GROR | 20 (40 μL) | 200 μL |
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| ACTR1A-ARMC4-20-GRGO | 20 (40 μL) | 200 μL |
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| ACTR1A-ARMC4-20-GRGR | 20 (40 μL) | 200 μL |
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| ACTR1A-ARMC4-20-GRAQ | 20 (40 μL) | 200 μL |
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| ACTR1A-ARMC4-20-AQRE | 20 (40 μL) | 200 μL |
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| ACTR1A-ARMC4-20-AQOR | 20 (40 μL) | 200 μL |
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| ACTR1A-ARMC4-20-AQGO | 20 (40 μL) | 200 μL |
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| ACTR1A-ARMC4-20-AQGR | 20 (40 μL) | 200 μL |
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| ACTR1A-ARMC4-20-AQAQ | 20 (40 μL) | 200 μL |
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ACTR1A Gene Summary
This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin. [provided by RefSeq, Jul 2008]
Gene Name: ARP1 Actin Related Protein 1 Homolog A
Chromosome: CHR10: 104238985 -104262512
Locus: 10q24.32
ARMC4 Gene Summary
The protein encoded by this gene contains ten Armadillo repeat motifs (ARMs) and one HEAT repeat, and is thought to be involved in ciliary and flagellar movement. This protein has been shown to localize to the ciliary axonemes and at the ciliary base of respiratory cells. Studies indicate that mutations in this gene cause partial outer dynein arm (ODA) defects in respiratory cilia. The cilia of cells with mutations in this gene displayed either reduced ciliary beat frequency and amplitude, or, complete immotility. Some individuals with primary ciliary dyskensia (PCD) have been shown to have mutations in this gene. PCD is characterized by chronic airway disease and left/right body asymmetry defects. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]
Gene Name: Armadillo Repeat Containing 4
Chromosome: CHR10: 28101096 -28287977
Locus: 10p12.1
Gene Diseases
The ACTR1A ARMC4 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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