ACVR1-CCDC148 Fusion FISH Probe
The ACVR1-CCDC148 Fusion FISH Probe is used to confirm a fusion of the ACVR1 and CCDC148 genes. The fusion of the ACVR1 and CCDC148 genes has been associated with Lung Adenocarcinoma, and Uterine Corpus Endometrial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
|---|---|---|---|---|
| ACVR1-CCDC148-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
|
|
| ACVR1-CCDC148-20-RERE | 20 (40 μL) | 200 μL |
|
|
| ACVR1-CCDC148-20-REOR | 20 (40 μL) | 200 μL |
|
|
| ACVR1-CCDC148-20-REGO | 20 (40 μL) | 200 μL |
|
|
| ACVR1-CCDC148-20-REGR | 20 (40 μL) | 200 μL |
|
|
| ACVR1-CCDC148-20-REAQ | 20 (40 μL) | 200 μL |
|
|
| ACVR1-CCDC148-20-ORRE | 20 (40 μL) | 200 μL |
|
|
| ACVR1-CCDC148-20-OROR | 20 (40 μL) | 200 μL |
|
|
| ACVR1-CCDC148-20-ORGO | 20 (40 μL) | 200 μL |
|
|
| ACVR1-CCDC148-20-ORAQ | 20 (40 μL) | 200 μL |
|
|
| ACVR1-CCDC148-20-GORE | 20 (40 μL) | 200 μL |
|
|
| ACVR1-CCDC148-20-GOOR | 20 (40 μL) | 200 μL |
|
|
| ACVR1-CCDC148-20-GOGO | 20 (40 μL) | 200 μL |
|
|
| ACVR1-CCDC148-20-GOGR | 20 (40 μL) | 200 μL |
|
|
| ACVR1-CCDC148-20-GOAQ | 20 (40 μL) | 200 μL |
|
|
| ACVR1-CCDC148-20-GRRE | 20 (40 μL) | 200 μL |
|
|
| ACVR1-CCDC148-20-GROR | 20 (40 μL) | 200 μL |
|
|
| ACVR1-CCDC148-20-GRGO | 20 (40 μL) | 200 μL |
|
|
| ACVR1-CCDC148-20-GRGR | 20 (40 μL) | 200 μL |
|
|
| ACVR1-CCDC148-20-GRAQ | 20 (40 μL) | 200 μL |
|
|
| ACVR1-CCDC148-20-AQRE | 20 (40 μL) | 200 μL |
|
|
| ACVR1-CCDC148-20-AQOR | 20 (40 μL) | 200 μL |
|
|
| ACVR1-CCDC148-20-AQGO | 20 (40 μL) | 200 μL |
|
|
| ACVR1-CCDC148-20-AQGR | 20 (40 μL) | 200 μL |
|
|
| ACVR1-CCDC148-20-AQAQ | 20 (40 μL) | 200 μL |
|
ACVR1 Gene Summary
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008]
Gene Name: Activin A Receptor Type 1
Chromosome: CHR2: 158592957 -158732374
Locus: 2q24.1
CCDC148 Gene Summary
The Coiled-coil Domain Containing 148 (CCDC148) gene is located on chr2 :159027868-159313265 at 2q24.1.
Gene Name: Coiled-coil Domain Containing 148
Chromosome: CHR2: 159027868 -159313265
Locus: 2q24.1
Gene Diseases
The ACVR1 CCDC148 Fusion has been associated with the following diseases:
| Disease Name |
|---|
| Lung Adenocarcinoma |
| Uterine Corpus Endometrial Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
|---|