ACVR1-NFATC1 Fusion FISH Probe
The ACVR1-NFATC1 Fusion FISH Probe is used to confirm a fusion of the ACVR1 and NFATC1 genes. The fusion of the ACVR1 and NFATC1 genes has been associated with Ovarian Serous Cystadenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ACVR1-NFATC1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ACVR1-NFATC1-20-RERE | 20 (40 μL) | 200 μL |
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| ACVR1-NFATC1-20-REOR | 20 (40 μL) | 200 μL |
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| ACVR1-NFATC1-20-REGO | 20 (40 μL) | 200 μL |
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| ACVR1-NFATC1-20-REGR | 20 (40 μL) | 200 μL |
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| ACVR1-NFATC1-20-REAQ | 20 (40 μL) | 200 μL |
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| ACVR1-NFATC1-20-ORRE | 20 (40 μL) | 200 μL |
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| ACVR1-NFATC1-20-OROR | 20 (40 μL) | 200 μL |
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| ACVR1-NFATC1-20-ORGO | 20 (40 μL) | 200 μL |
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| ACVR1-NFATC1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ACVR1-NFATC1-20-GORE | 20 (40 μL) | 200 μL |
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| ACVR1-NFATC1-20-GOOR | 20 (40 μL) | 200 μL |
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| ACVR1-NFATC1-20-GOGO | 20 (40 μL) | 200 μL |
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| ACVR1-NFATC1-20-GOGR | 20 (40 μL) | 200 μL |
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| ACVR1-NFATC1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ACVR1-NFATC1-20-GRRE | 20 (40 μL) | 200 μL |
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| ACVR1-NFATC1-20-GROR | 20 (40 μL) | 200 μL |
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| ACVR1-NFATC1-20-GRGO | 20 (40 μL) | 200 μL |
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| ACVR1-NFATC1-20-GRGR | 20 (40 μL) | 200 μL |
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| ACVR1-NFATC1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ACVR1-NFATC1-20-AQRE | 20 (40 μL) | 200 μL |
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| ACVR1-NFATC1-20-AQOR | 20 (40 μL) | 200 μL |
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| ACVR1-NFATC1-20-AQGO | 20 (40 μL) | 200 μL |
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| ACVR1-NFATC1-20-AQGR | 20 (40 μL) | 200 μL |
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| ACVR1-NFATC1-20-AQAQ | 20 (40 μL) | 200 μL |
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ACVR1 Gene Summary
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008]
Gene Name: Activin A Receptor Type 1
Chromosome: CHR2: 158592957 -158732374
Locus: 2q24.1
NFATC1 Gene Summary
The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2013]
Gene Name: Nuclear Factor Of Activated T-cells 1
Chromosome: CHR18: 77155771 -77289323
Locus: 18q23
Gene Diseases
The ACVR1 NFATC1 Fusion has been associated with the following diseases:
| Disease Name |
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| Ovarian Serous Cystadenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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