ACVR2A-KANK1 Fusion FISH Probe
The ACVR2A-KANK1 Fusion FISH Probe is used to confirm a fusion of the ACVR2A and KANK1 genes. The fusion of the ACVR2A and KANK1 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ACVR2A-KANK1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ACVR2A-KANK1-20-RERE | 20 (40 μL) | 200 μL |
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| ACVR2A-KANK1-20-REOR | 20 (40 μL) | 200 μL |
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| ACVR2A-KANK1-20-REGO | 20 (40 μL) | 200 μL |
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| ACVR2A-KANK1-20-REGR | 20 (40 μL) | 200 μL |
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| ACVR2A-KANK1-20-REAQ | 20 (40 μL) | 200 μL |
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| ACVR2A-KANK1-20-ORRE | 20 (40 μL) | 200 μL |
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| ACVR2A-KANK1-20-OROR | 20 (40 μL) | 200 μL |
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| ACVR2A-KANK1-20-ORGO | 20 (40 μL) | 200 μL |
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| ACVR2A-KANK1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ACVR2A-KANK1-20-GORE | 20 (40 μL) | 200 μL |
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| ACVR2A-KANK1-20-GOOR | 20 (40 μL) | 200 μL |
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| ACVR2A-KANK1-20-GOGO | 20 (40 μL) | 200 μL |
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| ACVR2A-KANK1-20-GOGR | 20 (40 μL) | 200 μL |
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| ACVR2A-KANK1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ACVR2A-KANK1-20-GRRE | 20 (40 μL) | 200 μL |
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| ACVR2A-KANK1-20-GROR | 20 (40 μL) | 200 μL |
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| ACVR2A-KANK1-20-GRGO | 20 (40 μL) | 200 μL |
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| ACVR2A-KANK1-20-GRGR | 20 (40 μL) | 200 μL |
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| ACVR2A-KANK1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ACVR2A-KANK1-20-AQRE | 20 (40 μL) | 200 μL |
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| ACVR2A-KANK1-20-AQOR | 20 (40 μL) | 200 μL |
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| ACVR2A-KANK1-20-AQGO | 20 (40 μL) | 200 μL |
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| ACVR2A-KANK1-20-AQGR | 20 (40 μL) | 200 μL |
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| ACVR2A-KANK1-20-AQAQ | 20 (40 μL) | 200 μL |
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ACVR2A Gene Summary
This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013]
Gene Name: Activin A Receptor Type 2A
Chromosome: CHR2: 148602569 -148688393
Locus: 2q22.3-q23.1
KANK1 Gene Summary
The protein encoded by this gene belongs to the Kank family of proteins, which contain multiple ankyrin repeat domains. This family member functions in cytoskeleton formation by regulating actin polymerization. This gene is a candidate tumor suppressor for renal cell carcinoma. Mutations in this gene cause cerebral palsy spastic quadriplegic type 2, a central nervous system development disorder. A t(5;9) translocation results in fusion of the platelet-derived growth factor receptor beta gene (PDGFRB) on chromosome 5 with this gene in a myeloproliferative neoplasm featuring severe thrombocythemia. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 20. [provided by RefSeq, Dec 2014]
Gene Name: KN Motif And Ankyrin Repeat Domains 1
Chromosome: CHR9: 504702 -746103
Locus: 9p24.3
Gene Diseases
The ACVR2A KANK1 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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