ACVR2A-SUMO1 Fusion FISH Probe
The ACVR2A-SUMO1 Fusion FISH Probe is used to confirm a fusion of the ACVR2A and SUMO1 genes. The fusion of the ACVR2A and SUMO1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ACVR2A-SUMO1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ACVR2A-SUMO1-20-RERE | 20 (40 μL) | 200 μL |
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| ACVR2A-SUMO1-20-REOR | 20 (40 μL) | 200 μL |
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| ACVR2A-SUMO1-20-REGO | 20 (40 μL) | 200 μL |
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| ACVR2A-SUMO1-20-REGR | 20 (40 μL) | 200 μL |
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| ACVR2A-SUMO1-20-REAQ | 20 (40 μL) | 200 μL |
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| ACVR2A-SUMO1-20-ORRE | 20 (40 μL) | 200 μL |
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| ACVR2A-SUMO1-20-OROR | 20 (40 μL) | 200 μL |
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| ACVR2A-SUMO1-20-ORGO | 20 (40 μL) | 200 μL |
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| ACVR2A-SUMO1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ACVR2A-SUMO1-20-GORE | 20 (40 μL) | 200 μL |
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| ACVR2A-SUMO1-20-GOOR | 20 (40 μL) | 200 μL |
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| ACVR2A-SUMO1-20-GOGO | 20 (40 μL) | 200 μL |
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| ACVR2A-SUMO1-20-GOGR | 20 (40 μL) | 200 μL |
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| ACVR2A-SUMO1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ACVR2A-SUMO1-20-GRRE | 20 (40 μL) | 200 μL |
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| ACVR2A-SUMO1-20-GROR | 20 (40 μL) | 200 μL |
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| ACVR2A-SUMO1-20-GRGO | 20 (40 μL) | 200 μL |
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| ACVR2A-SUMO1-20-GRGR | 20 (40 μL) | 200 μL |
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| ACVR2A-SUMO1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ACVR2A-SUMO1-20-AQRE | 20 (40 μL) | 200 μL |
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| ACVR2A-SUMO1-20-AQOR | 20 (40 μL) | 200 μL |
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| ACVR2A-SUMO1-20-AQGO | 20 (40 μL) | 200 μL |
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| ACVR2A-SUMO1-20-AQGR | 20 (40 μL) | 200 μL |
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| ACVR2A-SUMO1-20-AQAQ | 20 (40 μL) | 200 μL |
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ACVR2A Gene Summary
This gene encodes a receptor that mediates the functions of activins, which are members of the transforming growth factor-beta (TGF-beta) superfamily involved in diverse biological processes. The encoded protein is a transmembrane serine-threonine kinase receptor which mediates signaling by forming heterodimeric complexes with various combinations of type I and type II receptors and ligands in a cell-specific manner. The encoded type II receptor is primarily involved in ligand-binding and includes an extracellular ligand-binding domain, a transmembrane domain and a cytoplasmic serine-threonine kinase domain. This gene may be associated with susceptibility to preeclampsia, a pregnancy-related disease which can result in maternal and fetal morbidity and mortality. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jun 2013]
Gene Name: Activin A Receptor Type 2A
Chromosome: CHR2: 148602569 -148688393
Locus: 2q22.3-q23.1
SUMO1 Gene Summary
This gene encodes a protein that is a member of the SUMO (small ubiquitin-like modifier) protein family. It functions in a manner similar to ubiquitin in that it is bound to target proteins as part of a post-translational modification system. However, unlike ubiquitin which targets proteins for degradation, this protein is involved in a variety of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability. It is not active until the last four amino acids of the carboxy-terminus have been cleaved off. Several pseudogenes have been reported for this gene. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]
Gene Name: Small Ubiquitin-like Modifier 1
Chromosome: CHR2: 203070902 -203103322
Locus: 2q33.1
Gene Diseases
The ACVR2A SUMO1 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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