ADAM15-CHD1L Fusion FISH Probe
The ADAM15-CHD1L Fusion FISH Probe is used to confirm a fusion of the ADAM15 and CHD1L genes. The fusion of the ADAM15 and CHD1L genes has been associated with Pancreatic Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ADAM15-CHD1L-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ADAM15-CHD1L-20-RERE | 20 (40 μL) | 200 μL |
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| ADAM15-CHD1L-20-REOR | 20 (40 μL) | 200 μL |
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| ADAM15-CHD1L-20-REGO | 20 (40 μL) | 200 μL |
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| ADAM15-CHD1L-20-REGR | 20 (40 μL) | 200 μL |
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| ADAM15-CHD1L-20-REAQ | 20 (40 μL) | 200 μL |
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| ADAM15-CHD1L-20-ORRE | 20 (40 μL) | 200 μL |
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| ADAM15-CHD1L-20-OROR | 20 (40 μL) | 200 μL |
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| ADAM15-CHD1L-20-ORGO | 20 (40 μL) | 200 μL |
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| ADAM15-CHD1L-20-ORAQ | 20 (40 μL) | 200 μL |
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| ADAM15-CHD1L-20-GORE | 20 (40 μL) | 200 μL |
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| ADAM15-CHD1L-20-GOOR | 20 (40 μL) | 200 μL |
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| ADAM15-CHD1L-20-GOGO | 20 (40 μL) | 200 μL |
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| ADAM15-CHD1L-20-GOGR | 20 (40 μL) | 200 μL |
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| ADAM15-CHD1L-20-GOAQ | 20 (40 μL) | 200 μL |
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| ADAM15-CHD1L-20-GRRE | 20 (40 μL) | 200 μL |
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| ADAM15-CHD1L-20-GROR | 20 (40 μL) | 200 μL |
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| ADAM15-CHD1L-20-GRGO | 20 (40 μL) | 200 μL |
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| ADAM15-CHD1L-20-GRGR | 20 (40 μL) | 200 μL |
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| ADAM15-CHD1L-20-GRAQ | 20 (40 μL) | 200 μL |
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| ADAM15-CHD1L-20-AQRE | 20 (40 μL) | 200 μL |
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| ADAM15-CHD1L-20-AQOR | 20 (40 μL) | 200 μL |
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| ADAM15-CHD1L-20-AQGO | 20 (40 μL) | 200 μL |
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| ADAM15-CHD1L-20-AQGR | 20 (40 μL) | 200 μL |
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| ADAM15-CHD1L-20-AQAQ | 20 (40 μL) | 200 μL |
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ADAM15 Gene Summary
The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Gene Name: ADAM Metallopeptidase Domain 15
Chromosome: CHR1: 155023761 -155035252
Locus: 1q21.3
CHD1L Gene Summary
This gene encodes a DNA helicase protein involved in DNA repair. The protein converts ATP to add poly(ADP-ribose) as it regulates chromatin relaxation following DNA damage. Overexpression of this gene has been linked to several types of cancers. [provided by RefSeq, Feb 2017]
Gene Name: Chromodomain Helicase DNA Binding Protein 1 Like
Chromosome: CHR1: 146714290 -146767443
Locus: 1q21.1
Gene Diseases
The ADAM15 CHD1L Fusion has been associated with the following diseases:
| Disease Name |
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| Pancreatic Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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