ADAM15-DCST1 Fusion FISH Probe
The ADAM15-DCST1 Fusion FISH Probe is used to confirm a fusion of the ADAM15 and DCST1 genes. The fusion of the ADAM15 and DCST1 genes has been associated with Kidney Renal Clear Cell Carcinoma, and Liver Hepatocellular Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ADAM15-DCST1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ADAM15-DCST1-20-RERE | 20 (40 μL) | 200 μL |
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| ADAM15-DCST1-20-REOR | 20 (40 μL) | 200 μL |
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| ADAM15-DCST1-20-REGO | 20 (40 μL) | 200 μL |
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| ADAM15-DCST1-20-REGR | 20 (40 μL) | 200 μL |
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| ADAM15-DCST1-20-REAQ | 20 (40 μL) | 200 μL |
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| ADAM15-DCST1-20-ORRE | 20 (40 μL) | 200 μL |
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| ADAM15-DCST1-20-OROR | 20 (40 μL) | 200 μL |
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| ADAM15-DCST1-20-ORGO | 20 (40 μL) | 200 μL |
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| ADAM15-DCST1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ADAM15-DCST1-20-GORE | 20 (40 μL) | 200 μL |
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| ADAM15-DCST1-20-GOOR | 20 (40 μL) | 200 μL |
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| ADAM15-DCST1-20-GOGO | 20 (40 μL) | 200 μL |
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| ADAM15-DCST1-20-GOGR | 20 (40 μL) | 200 μL |
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| ADAM15-DCST1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ADAM15-DCST1-20-GRRE | 20 (40 μL) | 200 μL |
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| ADAM15-DCST1-20-GROR | 20 (40 μL) | 200 μL |
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| ADAM15-DCST1-20-GRGO | 20 (40 μL) | 200 μL |
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| ADAM15-DCST1-20-GRGR | 20 (40 μL) | 200 μL |
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| ADAM15-DCST1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ADAM15-DCST1-20-AQRE | 20 (40 μL) | 200 μL |
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| ADAM15-DCST1-20-AQOR | 20 (40 μL) | 200 μL |
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| ADAM15-DCST1-20-AQGO | 20 (40 μL) | 200 μL |
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| ADAM15-DCST1-20-AQGR | 20 (40 μL) | 200 μL |
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| ADAM15-DCST1-20-AQAQ | 20 (40 μL) | 200 μL |
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ADAM15 Gene Summary
The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Gene Name: ADAM Metallopeptidase Domain 15
Chromosome: CHR1: 155023761 -155035252
Locus: 1q21.3
DCST1 Gene Summary
This gene encodes a protein with a domain similar to one found in dendritic cells (PMID:11169400) which play a key role in antigen processing and display for immune responses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Gene Name: DC-STAMP Domain Containing 1
Chromosome: CHR1: 155006281 -155023406
Locus: 1q21.3
Gene Diseases
The ADAM15 DCST1 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Clear Cell Carcinoma |
| Liver Hepatocellular Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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