ADAM17-YWHAQ Fusion FISH Probe
The ADAM17-YWHAQ Fusion FISH Probe is used to confirm a fusion of the ADAM17 and YWHAQ genes. The fusion of the ADAM17 and YWHAQ genes has been associated with Glioblastoma Multiforme. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ADAM17-YWHAQ-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-RERE | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-REOR | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-REGO | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-REGR | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-REAQ | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-ORRE | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-OROR | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-ORGO | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-ORAQ | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-GORE | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-GOOR | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-GOGO | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-GOGR | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-GOAQ | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-GRRE | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-GROR | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-GRGO | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-GRGR | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-GRAQ | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-AQRE | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-AQOR | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-AQGO | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-AQGR | 20 (40 μL) | 200 μL |
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| ADAM17-YWHAQ-20-AQAQ | 20 (40 μL) | 200 μL |
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ADAM17 Gene Summary
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The encoded preproprotein is proteolytically processed to generate the mature protease. The encoded protease functions in the ectodomain shedding of tumor necrosis factor-alpha, in which soluble tumor necrosis factor-alpha is released from the membrane-bound precursor. This protease also functions in the processing of numerous other substrates, including cell adhesion proteins, cytokine and growth factor receptors and epidermal growth factor (EGF) receptor ligands. The encoded protein also plays a prominent role in the activation of the Notch signaling pathway. Elevated expression of this gene has been observed in specific cell types derived from psoriasis, rheumatoid arthritis, multiple sclerosis and Crohn's disease patients, suggesting that the encoded protein may play a role in autoimmune disease. [provided by RefSeq, Feb 2016]
Gene Name: ADAM Metallopeptidase Domain 17
Chromosome: CHR2: 9629410 -9695917
Locus: 2p25.1
YWHAQ Gene Summary
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008]
Gene Name: Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase Activation Protein Theta
Chromosome: CHR2: 9724105 -9771106
Locus: 2p25.1
Gene Diseases
The ADAM17 YWHAQ Fusion has been associated with the following diseases:
| Disease Name |
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| Glioblastoma Multiforme |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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