ADAM22-ASB4 Fusion FISH Probe
The ADAM22-ASB4 Fusion FISH Probe is used to confirm a fusion of the ADAM22 and ASB4 genes. The fusion of the ADAM22 and ASB4 genes has been associated with Kidney Renal Papillary Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ADAM22-ASB4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ADAM22-ASB4-20-RERE | 20 (40 μL) | 200 μL |
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| ADAM22-ASB4-20-REOR | 20 (40 μL) | 200 μL |
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| ADAM22-ASB4-20-REGO | 20 (40 μL) | 200 μL |
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| ADAM22-ASB4-20-REGR | 20 (40 μL) | 200 μL |
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| ADAM22-ASB4-20-REAQ | 20 (40 μL) | 200 μL |
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| ADAM22-ASB4-20-ORRE | 20 (40 μL) | 200 μL |
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| ADAM22-ASB4-20-OROR | 20 (40 μL) | 200 μL |
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| ADAM22-ASB4-20-ORGO | 20 (40 μL) | 200 μL |
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| ADAM22-ASB4-20-ORAQ | 20 (40 μL) | 200 μL |
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| ADAM22-ASB4-20-GORE | 20 (40 μL) | 200 μL |
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| ADAM22-ASB4-20-GOOR | 20 (40 μL) | 200 μL |
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| ADAM22-ASB4-20-GOGO | 20 (40 μL) | 200 μL |
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| ADAM22-ASB4-20-GOGR | 20 (40 μL) | 200 μL |
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| ADAM22-ASB4-20-GOAQ | 20 (40 μL) | 200 μL |
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| ADAM22-ASB4-20-GRRE | 20 (40 μL) | 200 μL |
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| ADAM22-ASB4-20-GROR | 20 (40 μL) | 200 μL |
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| ADAM22-ASB4-20-GRGO | 20 (40 μL) | 200 μL |
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| ADAM22-ASB4-20-GRGR | 20 (40 μL) | 200 μL |
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| ADAM22-ASB4-20-GRAQ | 20 (40 μL) | 200 μL |
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| ADAM22-ASB4-20-AQRE | 20 (40 μL) | 200 μL |
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| ADAM22-ASB4-20-AQOR | 20 (40 μL) | 200 μL |
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| ADAM22-ASB4-20-AQGO | 20 (40 μL) | 200 μL |
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| ADAM22-ASB4-20-AQGR | 20 (40 μL) | 200 μL |
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| ADAM22-ASB4-20-AQAQ | 20 (40 μL) | 200 μL |
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ASB4 Gene Summary
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but some of the full length sequences are not known. [provided by RefSeq, Jul 2008]
Gene Name: Ankyrin Repeat And SOCS Box Containing 4
Chromosome: CHR7: 95115212 -95169543
Locus: 7q21.3
ADAM22 Gene Summary
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Unlike other members of the ADAM protein family, the protein encoded by this gene lacks metalloprotease activity since it has no zinc-binding motif. This gene is highly expressed in the brain and may function as an integrin ligand in the brain. In mice, it has been shown to be essential for correct myelination in the peripheral nervous system. Alternative splicing results in several transcript variants.[provided by RefSeq, Dec 2010]
Gene Name: ADAM Metallopeptidase Domain 22
Chromosome: CHR7: 87563565 -87832204
Locus: 7q21.12
Gene Diseases
The ADAM22 ASB4 Fusion has been associated with the following diseases:
| Disease Name |
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| Kidney Renal Papillary Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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