ADAMTS17-SLC12A1 Fusion FISH Probe
The ADAMTS17-SLC12A1 Fusion FISH Probe is used to confirm a fusion of the ADAMTS17 and SLC12A1 genes. The fusion of the ADAMTS17 and SLC12A1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ADAMTS17-SLC12A1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ADAMTS17-SLC12A1-20-RERE | 20 (40 μL) | 200 μL |
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| ADAMTS17-SLC12A1-20-REOR | 20 (40 μL) | 200 μL |
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| ADAMTS17-SLC12A1-20-REGO | 20 (40 μL) | 200 μL |
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| ADAMTS17-SLC12A1-20-REGR | 20 (40 μL) | 200 μL |
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| ADAMTS17-SLC12A1-20-REAQ | 20 (40 μL) | 200 μL |
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| ADAMTS17-SLC12A1-20-ORRE | 20 (40 μL) | 200 μL |
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| ADAMTS17-SLC12A1-20-OROR | 20 (40 μL) | 200 μL |
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| ADAMTS17-SLC12A1-20-ORGO | 20 (40 μL) | 200 μL |
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| ADAMTS17-SLC12A1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ADAMTS17-SLC12A1-20-GORE | 20 (40 μL) | 200 μL |
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| ADAMTS17-SLC12A1-20-GOOR | 20 (40 μL) | 200 μL |
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| ADAMTS17-SLC12A1-20-GOGO | 20 (40 μL) | 200 μL |
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| ADAMTS17-SLC12A1-20-GOGR | 20 (40 μL) | 200 μL |
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| ADAMTS17-SLC12A1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ADAMTS17-SLC12A1-20-GRRE | 20 (40 μL) | 200 μL |
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| ADAMTS17-SLC12A1-20-GROR | 20 (40 μL) | 200 μL |
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| ADAMTS17-SLC12A1-20-GRGO | 20 (40 μL) | 200 μL |
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| ADAMTS17-SLC12A1-20-GRGR | 20 (40 μL) | 200 μL |
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| ADAMTS17-SLC12A1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ADAMTS17-SLC12A1-20-AQRE | 20 (40 μL) | 200 μL |
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| ADAMTS17-SLC12A1-20-AQOR | 20 (40 μL) | 200 μL |
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| ADAMTS17-SLC12A1-20-AQGO | 20 (40 μL) | 200 μL |
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| ADAMTS17-SLC12A1-20-AQGR | 20 (40 μL) | 200 μL |
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| ADAMTS17-SLC12A1-20-AQAQ | 20 (40 μL) | 200 μL |
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SLC12A1 Gene Summary
This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.[provided by RefSeq, May 2010]
Gene Name: Solute Carrier Family 12 Member 1
Chromosome: CHR15: 48498497 -48596275
Locus: 15q21.1
ADAMTS17 Gene Summary
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. ADAMTS family members share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature protein, which may promote breast cancer cell growth and survival. Mutations in this gene are associated with a Weill-Marchesani-like syndrome, which is characterized by lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature. [provided by RefSeq, May 2016]
Gene Name: ADAM Metallopeptidase With Thrombospondin Type 1 Motif 17
Chromosome: CHR15: 100511642 -100882183
Locus: 15q26.3
Gene Diseases
The ADAMTS17 SLC12A1 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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