ADAT1-KARS Fusion FISH Probe
The ADAT1-KARS Fusion FISH Probe is used to confirm a fusion of the ADAT1 and KARS genes. The fusion of the ADAT1 and KARS genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ADAT1-KARS-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ADAT1-KARS-20-RERE | 20 (40 μL) | 200 μL |
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| ADAT1-KARS-20-REOR | 20 (40 μL) | 200 μL |
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| ADAT1-KARS-20-REGO | 20 (40 μL) | 200 μL |
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| ADAT1-KARS-20-REGR | 20 (40 μL) | 200 μL |
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| ADAT1-KARS-20-REAQ | 20 (40 μL) | 200 μL |
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| ADAT1-KARS-20-ORRE | 20 (40 μL) | 200 μL |
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| ADAT1-KARS-20-OROR | 20 (40 μL) | 200 μL |
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| ADAT1-KARS-20-ORGO | 20 (40 μL) | 200 μL |
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| ADAT1-KARS-20-ORAQ | 20 (40 μL) | 200 μL |
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| ADAT1-KARS-20-GORE | 20 (40 μL) | 200 μL |
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| ADAT1-KARS-20-GOOR | 20 (40 μL) | 200 μL |
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| ADAT1-KARS-20-GOGO | 20 (40 μL) | 200 μL |
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| ADAT1-KARS-20-GOGR | 20 (40 μL) | 200 μL |
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| ADAT1-KARS-20-GOAQ | 20 (40 μL) | 200 μL |
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| ADAT1-KARS-20-GRRE | 20 (40 μL) | 200 μL |
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| ADAT1-KARS-20-GROR | 20 (40 μL) | 200 μL |
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| ADAT1-KARS-20-GRGO | 20 (40 μL) | 200 μL |
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| ADAT1-KARS-20-GRGR | 20 (40 μL) | 200 μL |
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| ADAT1-KARS-20-GRAQ | 20 (40 μL) | 200 μL |
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| ADAT1-KARS-20-AQRE | 20 (40 μL) | 200 μL |
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| ADAT1-KARS-20-AQOR | 20 (40 μL) | 200 μL |
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| ADAT1-KARS-20-AQGO | 20 (40 μL) | 200 μL |
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| ADAT1-KARS-20-AQGR | 20 (40 μL) | 200 μL |
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| ADAT1-KARS-20-AQAQ | 20 (40 μL) | 200 μL |
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KARS Gene Summary
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Lysyl-tRNA Synthetase
Chromosome: CHR16: 75661621 -75681585
Locus: 16q23.1
ADAT1 Gene Summary
This gene is a member of the ADAR (adenosine deaminase acting on RNA) family. Using site-specific adenosine modification, proteins encoded by these genes participate in the pre-mRNA editing of nuclear transcripts. The protein encoded by this gene, tRNA-specific adenosine deaminase 1, is responsible for the deamination of adenosine 37 to inosine in eukaryotic tRNA. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]
Gene Name: Adenosine Deaminase, TRNA Specific 1
Chromosome: CHR16: 75632246 -75657221
Locus: 16q23.1
Gene Diseases
The ADAT1 KARS Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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