AES-ELK3 Fusion FISH Probe
The AES-ELK3 Fusion FISH Probe is used to confirm a fusion of the AES and ELK3 genes. The fusion of the AES and ELK3 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AES-ELK3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AES-ELK3-20-RERE | 20 (40 μL) | 200 μL |
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| AES-ELK3-20-REOR | 20 (40 μL) | 200 μL |
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| AES-ELK3-20-REGO | 20 (40 μL) | 200 μL |
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| AES-ELK3-20-REGR | 20 (40 μL) | 200 μL |
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| AES-ELK3-20-REAQ | 20 (40 μL) | 200 μL |
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| AES-ELK3-20-ORRE | 20 (40 μL) | 200 μL |
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| AES-ELK3-20-OROR | 20 (40 μL) | 200 μL |
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| AES-ELK3-20-ORGO | 20 (40 μL) | 200 μL |
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| AES-ELK3-20-ORAQ | 20 (40 μL) | 200 μL |
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| AES-ELK3-20-GORE | 20 (40 μL) | 200 μL |
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| AES-ELK3-20-GOOR | 20 (40 μL) | 200 μL |
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| AES-ELK3-20-GOGO | 20 (40 μL) | 200 μL |
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| AES-ELK3-20-GOGR | 20 (40 μL) | 200 μL |
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| AES-ELK3-20-GOAQ | 20 (40 μL) | 200 μL |
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| AES-ELK3-20-GRRE | 20 (40 μL) | 200 μL |
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| AES-ELK3-20-GROR | 20 (40 μL) | 200 μL |
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| AES-ELK3-20-GRGO | 20 (40 μL) | 200 μL |
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| AES-ELK3-20-GRGR | 20 (40 μL) | 200 μL |
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| AES-ELK3-20-GRAQ | 20 (40 μL) | 200 μL |
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| AES-ELK3-20-AQRE | 20 (40 μL) | 200 μL |
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| AES-ELK3-20-AQOR | 20 (40 μL) | 200 μL |
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| AES-ELK3-20-AQGO | 20 (40 μL) | 200 μL |
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| AES-ELK3-20-AQGR | 20 (40 μL) | 200 μL |
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| AES-ELK3-20-AQAQ | 20 (40 μL) | 200 μL |
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AES Gene Summary
The protein encoded by this gene is similar in sequence to the amino terminus of Drosophila enhancer of split groucho, a protein involved in neurogenesis during embryonic development. The encoded protein, which belongs to the groucho/TLE family of proteins, can function as a homooligomer or as a heteroologimer with other family members to dominantly repress the expression of other family member genes. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Amino-terminal Enhancer Of Split
Chromosome: CHR19: 3052907 -3062964
Locus: 19p13.3
ELK3 Gene Summary
This gene encodes a member of the ETS-domain transcription factor family and the ternary complex factor (TCF) subfamily. Proteins in this subfamily regulate transcription when recruited by serum response factor to bind to serum response elements. This protein is activated by signal-induced phosphorylation; studies in rodents suggest that it is a transcriptional inhibitor in the absence of Ras, but activates transcription when Ras is present. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Gene Name: ELK3, ETS Transcription Factor
Chromosome: CHR12: 96588206 -96661606
Locus: 12q23.1
Gene Diseases
The AES ELK3 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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