AFF1-PTPN13 Fusion FISH Probe
The AFF1-PTPN13 Fusion FISH Probe is used to confirm a fusion of the AFF1 and PTPN13 genes. The fusion of the AFF1 and PTPN13 genes has been associated with Lung Adenocarcinoma, Bladder Urothelial Carcinoma, Bladder Urothelial Carcinoma, Lung Squamous Cell Carcinoma, Bladder Urothelial Carcinoma, Bladder Urothelial Carcinoma, and Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AFF1-PTPN13-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AFF1-PTPN13-20-RERE | 20 (40 μL) | 200 μL |
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| AFF1-PTPN13-20-REOR | 20 (40 μL) | 200 μL |
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| AFF1-PTPN13-20-REGO | 20 (40 μL) | 200 μL |
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| AFF1-PTPN13-20-REGR | 20 (40 μL) | 200 μL |
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| AFF1-PTPN13-20-REAQ | 20 (40 μL) | 200 μL |
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| AFF1-PTPN13-20-ORRE | 20 (40 μL) | 200 μL |
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| AFF1-PTPN13-20-OROR | 20 (40 μL) | 200 μL |
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| AFF1-PTPN13-20-ORGO | 20 (40 μL) | 200 μL |
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| AFF1-PTPN13-20-ORAQ | 20 (40 μL) | 200 μL |
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| AFF1-PTPN13-20-GORE | 20 (40 μL) | 200 μL |
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| AFF1-PTPN13-20-GOOR | 20 (40 μL) | 200 μL |
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| AFF1-PTPN13-20-GOGO | 20 (40 μL) | 200 μL |
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| AFF1-PTPN13-20-GOGR | 20 (40 μL) | 200 μL |
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| AFF1-PTPN13-20-GOAQ | 20 (40 μL) | 200 μL |
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| AFF1-PTPN13-20-GRRE | 20 (40 μL) | 200 μL |
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| AFF1-PTPN13-20-GROR | 20 (40 μL) | 200 μL |
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| AFF1-PTPN13-20-GRGO | 20 (40 μL) | 200 μL |
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| AFF1-PTPN13-20-GRGR | 20 (40 μL) | 200 μL |
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| AFF1-PTPN13-20-GRAQ | 20 (40 μL) | 200 μL |
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| AFF1-PTPN13-20-AQRE | 20 (40 μL) | 200 μL |
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| AFF1-PTPN13-20-AQOR | 20 (40 μL) | 200 μL |
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| AFF1-PTPN13-20-AQGO | 20 (40 μL) | 200 μL |
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| AFF1-PTPN13-20-AQGR | 20 (40 μL) | 200 μL |
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| AFF1-PTPN13-20-AQAQ | 20 (40 μL) | 200 μL |
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AFF1 Gene Summary
This gene encodes a member of the AF4/ lymphoid nuclear protein related to the Fragile X E syndrome (FRAXE) family of proteins, which have been implicated in human childhood lymphoblastic leukemia, fragile chromosome X intellectual disability, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]
Gene Name: AF4/FMR2 Family Member 1
Chromosome: CHR4: 87856153 -88062206
Locus: 4q21.3-q22.1
PTPN13 Gene Summary
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP is a large intracellular protein. It has a catalytic PTP domain at its C-terminus and two major structural domains: a region with five PDZ domains and a FERM domain that binds to plasma membrane and cytoskeletal elements. This PTP was found to interact with, and dephosphorylate, Fas receptor and IkappaBalpha through the PDZ domains. This suggests it has a role in Fas mediated programmed cell death. This PTP was also shown to interact with GTPase-activating protein, and thus may function as a regulator of Rho signaling pathways. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported. [provided by RefSeq, Oct 2008]
Gene Name: Protein Tyrosine Phosphatase, Non-receptor Type 13
Chromosome: CHR4: 87515467 -87736328
Locus: 4q21.3
Gene Diseases
The AFF1 PTPN13 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
| Bladder Urothelial Carcinoma |
| Bladder Urothelial Carcinoma |
| Lung Squamous Cell Carcinoma |
| Bladder Urothelial Carcinoma |
| Bladder Urothelial Carcinoma |
| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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