AFF1-WWOX Fusion FISH Probe
The AFF1-WWOX Fusion FISH Probe is used to confirm a fusion of the AFF1 and WWOX genes. The fusion of the AFF1 and WWOX genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AFF1-WWOX-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AFF1-WWOX-20-RERE | 20 (40 μL) | 200 μL |
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| AFF1-WWOX-20-REOR | 20 (40 μL) | 200 μL |
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| AFF1-WWOX-20-REGO | 20 (40 μL) | 200 μL |
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| AFF1-WWOX-20-REGR | 20 (40 μL) | 200 μL |
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| AFF1-WWOX-20-REAQ | 20 (40 μL) | 200 μL |
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| AFF1-WWOX-20-ORRE | 20 (40 μL) | 200 μL |
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| AFF1-WWOX-20-OROR | 20 (40 μL) | 200 μL |
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| AFF1-WWOX-20-ORGO | 20 (40 μL) | 200 μL |
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| AFF1-WWOX-20-ORAQ | 20 (40 μL) | 200 μL |
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| AFF1-WWOX-20-GORE | 20 (40 μL) | 200 μL |
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| AFF1-WWOX-20-GOOR | 20 (40 μL) | 200 μL |
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| AFF1-WWOX-20-GOGO | 20 (40 μL) | 200 μL |
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| AFF1-WWOX-20-GOGR | 20 (40 μL) | 200 μL |
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| AFF1-WWOX-20-GOAQ | 20 (40 μL) | 200 μL |
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| AFF1-WWOX-20-GRRE | 20 (40 μL) | 200 μL |
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| AFF1-WWOX-20-GROR | 20 (40 μL) | 200 μL |
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| AFF1-WWOX-20-GRGO | 20 (40 μL) | 200 μL |
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| AFF1-WWOX-20-GRGR | 20 (40 μL) | 200 μL |
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| AFF1-WWOX-20-GRAQ | 20 (40 μL) | 200 μL |
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| AFF1-WWOX-20-AQRE | 20 (40 μL) | 200 μL |
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| AFF1-WWOX-20-AQOR | 20 (40 μL) | 200 μL |
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| AFF1-WWOX-20-AQGO | 20 (40 μL) | 200 μL |
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| AFF1-WWOX-20-AQGR | 20 (40 μL) | 200 μL |
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| AFF1-WWOX-20-AQAQ | 20 (40 μL) | 200 μL |
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AFF1 Gene Summary
This gene encodes a member of the AF4/ lymphoid nuclear protein related to the Fragile X E syndrome (FRAXE) family of proteins, which have been implicated in human childhood lymphoblastic leukemia, fragile chromosome X intellectual disability, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2017]
Gene Name: AF4/FMR2 Family Member 1
Chromosome: CHR4: 87856153 -88062206
Locus: 4q21.3-q22.1
WWOX Gene Summary
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
Gene Name: WW Domain Containing Oxidoreductase
Chromosome: CHR16: 78133326 -79246564
Locus: 16q23.1-q23.2
Gene Diseases
The AFF1 WWOX Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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