AFF3-HDAC5 Fusion FISH Probe
The AFF3-HDAC5 Fusion FISH Probe is used to confirm a fusion of the AFF3 and HDAC5 genes. The fusion of the AFF3 and HDAC5 genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AFF3-HDAC5-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AFF3-HDAC5-20-RERE | 20 (40 μL) | 200 μL |
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| AFF3-HDAC5-20-REOR | 20 (40 μL) | 200 μL |
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| AFF3-HDAC5-20-REGO | 20 (40 μL) | 200 μL |
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| AFF3-HDAC5-20-REGR | 20 (40 μL) | 200 μL |
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| AFF3-HDAC5-20-REAQ | 20 (40 μL) | 200 μL |
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| AFF3-HDAC5-20-ORRE | 20 (40 μL) | 200 μL |
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| AFF3-HDAC5-20-OROR | 20 (40 μL) | 200 μL |
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| AFF3-HDAC5-20-ORGO | 20 (40 μL) | 200 μL |
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| AFF3-HDAC5-20-ORAQ | 20 (40 μL) | 200 μL |
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| AFF3-HDAC5-20-GORE | 20 (40 μL) | 200 μL |
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| AFF3-HDAC5-20-GOOR | 20 (40 μL) | 200 μL |
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| AFF3-HDAC5-20-GOGO | 20 (40 μL) | 200 μL |
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| AFF3-HDAC5-20-GOGR | 20 (40 μL) | 200 μL |
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| AFF3-HDAC5-20-GOAQ | 20 (40 μL) | 200 μL |
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| AFF3-HDAC5-20-GRRE | 20 (40 μL) | 200 μL |
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| AFF3-HDAC5-20-GROR | 20 (40 μL) | 200 μL |
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| AFF3-HDAC5-20-GRGO | 20 (40 μL) | 200 μL |
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| AFF3-HDAC5-20-GRGR | 20 (40 μL) | 200 μL |
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| AFF3-HDAC5-20-GRAQ | 20 (40 μL) | 200 μL |
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| AFF3-HDAC5-20-AQRE | 20 (40 μL) | 200 μL |
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| AFF3-HDAC5-20-AQOR | 20 (40 μL) | 200 μL |
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| AFF3-HDAC5-20-AQGO | 20 (40 μL) | 200 μL |
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| AFF3-HDAC5-20-AQGR | 20 (40 μL) | 200 μL |
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| AFF3-HDAC5-20-AQAQ | 20 (40 μL) | 200 μL |
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AFF3 Gene Summary
This gene encodes a tissue-restricted nuclear transcriptional activator that is preferentially expressed in lymphoid tissue. Isolation of this protein initially defined a highly conserved LAF4/MLLT2 gene family of nuclear transcription factors that may function in lymphoid development and oncogenesis. In some ALL patients, this gene has been found fused to the gene for MLL. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: AF4/FMR2 Family Member 3
Chromosome: CHR2: 100163715 -100759037
Locus: 2q11.2
HDAC5 Gene Summary
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Name: Histone Deacetylase 5
Chromosome: CHR17: 42154120 -42201014
Locus: 17q21.31
Gene Diseases
The AFF3 HDAC5 Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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