AGAP3-GRM3 Fusion FISH Probe
The AGAP3-GRM3 Fusion FISH Probe is used to confirm a fusion of the AGAP3 and GRM3 genes. The fusion of the AGAP3 and GRM3 genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AGAP3-GRM3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AGAP3-GRM3-20-RERE | 20 (40 μL) | 200 μL |
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| AGAP3-GRM3-20-REOR | 20 (40 μL) | 200 μL |
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| AGAP3-GRM3-20-REGO | 20 (40 μL) | 200 μL |
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| AGAP3-GRM3-20-REGR | 20 (40 μL) | 200 μL |
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| AGAP3-GRM3-20-REAQ | 20 (40 μL) | 200 μL |
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| AGAP3-GRM3-20-ORRE | 20 (40 μL) | 200 μL |
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| AGAP3-GRM3-20-OROR | 20 (40 μL) | 200 μL |
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| AGAP3-GRM3-20-ORGO | 20 (40 μL) | 200 μL |
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| AGAP3-GRM3-20-ORAQ | 20 (40 μL) | 200 μL |
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| AGAP3-GRM3-20-GORE | 20 (40 μL) | 200 μL |
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| AGAP3-GRM3-20-GOOR | 20 (40 μL) | 200 μL |
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| AGAP3-GRM3-20-GOGO | 20 (40 μL) | 200 μL |
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| AGAP3-GRM3-20-GOGR | 20 (40 μL) | 200 μL |
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| AGAP3-GRM3-20-GOAQ | 20 (40 μL) | 200 μL |
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| AGAP3-GRM3-20-GRRE | 20 (40 μL) | 200 μL |
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| AGAP3-GRM3-20-GROR | 20 (40 μL) | 200 μL |
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| AGAP3-GRM3-20-GRGO | 20 (40 μL) | 200 μL |
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| AGAP3-GRM3-20-GRGR | 20 (40 μL) | 200 μL |
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| AGAP3-GRM3-20-GRAQ | 20 (40 μL) | 200 μL |
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| AGAP3-GRM3-20-AQRE | 20 (40 μL) | 200 μL |
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| AGAP3-GRM3-20-AQOR | 20 (40 μL) | 200 μL |
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| AGAP3-GRM3-20-AQGO | 20 (40 μL) | 200 μL |
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| AGAP3-GRM3-20-AQGR | 20 (40 μL) | 200 μL |
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| AGAP3-GRM3-20-AQAQ | 20 (40 μL) | 200 μL |
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GRM3 Gene Summary
L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. [provided by RefSeq, Jul 2008]
Gene Name: Glutamate Metabotropic Receptor 3
Chromosome: CHR7: 86273229 -86494192
Locus: 7q21.11-q21.12
AGAP3 Gene Summary
This gene encodes an essential component of the N-methyl-D-aspartate (NMDA) receptor signaling complex which mediates long-term potentiation in synapses by linking activation of NMDA receptor to alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor trafficking. The encoded protein contains an N-terminal GTPase-like domain, a pleckstrin homology domain, an ArfGAP domain and several C-terminal ankryn repeat domains. [provided by RefSeq, Apr 2017]
Gene Name: ArfGAP With GTPase Domain, Ankyrin Repeat And PH Domain 3
Chromosome: CHR7: 150783825 -150841523
Locus: 7q36.1
Gene Diseases
The AGAP3 GRM3 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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