AGRN-BAD Fusion FISH Probe
The AGRN-BAD Fusion FISH Probe is used to confirm a fusion of the AGRN and BAD genes. The fusion of the AGRN and BAD genes has been associated with Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| AGRN-BAD-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| AGRN-BAD-20-RERE | 20 (40 μL) | 200 μL |
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| AGRN-BAD-20-REOR | 20 (40 μL) | 200 μL |
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| AGRN-BAD-20-REGO | 20 (40 μL) | 200 μL |
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| AGRN-BAD-20-REGR | 20 (40 μL) | 200 μL |
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| AGRN-BAD-20-REAQ | 20 (40 μL) | 200 μL |
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| AGRN-BAD-20-ORRE | 20 (40 μL) | 200 μL |
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| AGRN-BAD-20-OROR | 20 (40 μL) | 200 μL |
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| AGRN-BAD-20-ORGO | 20 (40 μL) | 200 μL |
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| AGRN-BAD-20-ORAQ | 20 (40 μL) | 200 μL |
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| AGRN-BAD-20-GORE | 20 (40 μL) | 200 μL |
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| AGRN-BAD-20-GOOR | 20 (40 μL) | 200 μL |
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| AGRN-BAD-20-GOGO | 20 (40 μL) | 200 μL |
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| AGRN-BAD-20-GOGR | 20 (40 μL) | 200 μL |
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| AGRN-BAD-20-GOAQ | 20 (40 μL) | 200 μL |
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| AGRN-BAD-20-GRRE | 20 (40 μL) | 200 μL |
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| AGRN-BAD-20-GROR | 20 (40 μL) | 200 μL |
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| AGRN-BAD-20-GRGO | 20 (40 μL) | 200 μL |
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| AGRN-BAD-20-GRGR | 20 (40 μL) | 200 μL |
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| AGRN-BAD-20-GRAQ | 20 (40 μL) | 200 μL |
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| AGRN-BAD-20-AQRE | 20 (40 μL) | 200 μL |
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| AGRN-BAD-20-AQOR | 20 (40 μL) | 200 μL |
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| AGRN-BAD-20-AQGO | 20 (40 μL) | 200 μL |
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| AGRN-BAD-20-AQGR | 20 (40 μL) | 200 μL |
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| AGRN-BAD-20-AQAQ | 20 (40 μL) | 200 μL |
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BAD Gene Summary
The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Jul 2008]
Gene Name: BCL2 Associated Agonist Of Cell Death
Chromosome: CHR11: 64037299 -64052176
Locus: 11q13.1
AGRN Gene Summary
This gene encodes one of several proteins that are critical in the development of the neuromuscular junction (NMJ), as identified in mouse knock-out studies. The encoded protein contains several laminin G, Kazal type serine protease inhibitor, and epidermal growth factor domains. Additional post-translational modifications occur to add glycosaminoglycans and disulfide bonds. In one family with congenital myasthenic syndrome affecting limb-girdle muscles, a mutation in this gene was found. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]
Gene Name: Agrin
Chromosome: CHR1: 955502 -991499
Locus: 1p36.33
Gene Diseases
The AGRN BAD Fusion has been associated with the following diseases:
| Disease Name |
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| Cervical Squamous Cell Carcinoma And Endocervical Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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