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ANK3-ACTA2 Fusion FISH Probe

The ANK3-ACTA2 Fusion FISH Probe is used to confirm a fusion of the ANK3 and ACTA2 genes. The fusion of the ANK3 and ACTA2 genes has been associated with Colon Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
ANK3-ACTA2-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
ANK3-ACTA2-20-RERE 20 (40 μL) 200 μL
ANK3-ACTA2-20-REOR 20 (40 μL) 200 μL
ANK3-ACTA2-20-REGO 20 (40 μL) 200 μL
ANK3-ACTA2-20-REGR 20 (40 μL) 200 μL
ANK3-ACTA2-20-REAQ 20 (40 μL) 200 μL
ANK3-ACTA2-20-ORRE 20 (40 μL) 200 μL
ANK3-ACTA2-20-OROR 20 (40 μL) 200 μL
ANK3-ACTA2-20-ORGO 20 (40 μL) 200 μL
ANK3-ACTA2-20-ORAQ 20 (40 μL) 200 μL
ANK3-ACTA2-20-GORE 20 (40 μL) 200 μL
ANK3-ACTA2-20-GOOR 20 (40 μL) 200 μL
ANK3-ACTA2-20-GOGO 20 (40 μL) 200 μL
ANK3-ACTA2-20-GOGR 20 (40 μL) 200 μL
ANK3-ACTA2-20-GOAQ 20 (40 μL) 200 μL
ANK3-ACTA2-20-GRRE 20 (40 μL) 200 μL
ANK3-ACTA2-20-GROR 20 (40 μL) 200 μL
ANK3-ACTA2-20-GRGO 20 (40 μL) 200 μL
ANK3-ACTA2-20-GRGR 20 (40 μL) 200 μL
ANK3-ACTA2-20-GRAQ 20 (40 μL) 200 μL
ANK3-ACTA2-20-AQRE 20 (40 μL) 200 μL
ANK3-ACTA2-20-AQOR 20 (40 μL) 200 μL
ANK3-ACTA2-20-AQGO 20 (40 μL) 200 μL
ANK3-ACTA2-20-AQGR 20 (40 μL) 200 μL
ANK3-ACTA2-20-AQAQ 20 (40 μL) 200 μL

ACTA2 Gene Summary

This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, integrity, and intercellular signaling. The encoded protein is a smooth muscle actin that is involved in vascular contractility and blood pressure homeostasis. Mutations in this gene cause a variety of vascular diseases, such as thoracic aortic disease, coronary artery disease, stroke, and Moyamoya disease, as well as multisystemic smooth muscle dysfunction syndrome. [provided by RefSeq, Sep 2017]

Gene Name: Actin, Alpha 2, Smooth Muscle, Aorta

Chromosome: CHR10: 90694830 -90751147

Locus: 10q23.31

ANK3 Gene Summary

Ankyrins are a family of proteins that are believed to link the integral membrane proteins to the underlying spectrin-actin cytoskeleton and play key roles in activities such as cell motility, activation, proliferation, contact, and the maintenance of specialized membrane domains. Multiple isoforms of ankyrin with different affinities for various target proteins are expressed in a tissue-specific, developmentally regulated manner. Most ankyrins are typically composed of three structural domains: an amino-terminal domain containing multiple ankyrin repeats; a central region with a highly conserved spectrin binding domain; and a carboxy-terminal regulatory domain which is the least conserved and subject to variation. Ankyrin 3 is an immunologically distinct gene product from ankyrins 1 and 2, and was originally found at the axonal initial segment and nodes of Ranvier of neurons in the central and peripheral nervous systems. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]

Gene Name: Ankyrin 3

Chromosome: CHR10: 61786055 -62493284

Locus: 10q21.2

Gene Diseases

The ANK3 ACTA2 Fusion has been associated with the following diseases:

Disease Name
Colon Adenocarcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.