ANKRD11-TGIF1 Fusion FISH Probe
The ANKRD11-TGIF1 Fusion FISH Probe is used to confirm a fusion of the ANKRD11 and TGIF1 genes. The fusion of the ANKRD11 and TGIF1 genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ANKRD11-TGIF1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ANKRD11-TGIF1-20-RERE | 20 (40 μL) | 200 μL |
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| ANKRD11-TGIF1-20-REOR | 20 (40 μL) | 200 μL |
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| ANKRD11-TGIF1-20-REGO | 20 (40 μL) | 200 μL |
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| ANKRD11-TGIF1-20-REGR | 20 (40 μL) | 200 μL |
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| ANKRD11-TGIF1-20-REAQ | 20 (40 μL) | 200 μL |
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| ANKRD11-TGIF1-20-ORRE | 20 (40 μL) | 200 μL |
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| ANKRD11-TGIF1-20-OROR | 20 (40 μL) | 200 μL |
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| ANKRD11-TGIF1-20-ORGO | 20 (40 μL) | 200 μL |
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| ANKRD11-TGIF1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ANKRD11-TGIF1-20-GORE | 20 (40 μL) | 200 μL |
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| ANKRD11-TGIF1-20-GOOR | 20 (40 μL) | 200 μL |
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| ANKRD11-TGIF1-20-GOGO | 20 (40 μL) | 200 μL |
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| ANKRD11-TGIF1-20-GOGR | 20 (40 μL) | 200 μL |
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| ANKRD11-TGIF1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ANKRD11-TGIF1-20-GRRE | 20 (40 μL) | 200 μL |
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| ANKRD11-TGIF1-20-GROR | 20 (40 μL) | 200 μL |
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| ANKRD11-TGIF1-20-GRGO | 20 (40 μL) | 200 μL |
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| ANKRD11-TGIF1-20-GRGR | 20 (40 μL) | 200 μL |
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| ANKRD11-TGIF1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ANKRD11-TGIF1-20-AQRE | 20 (40 μL) | 200 μL |
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| ANKRD11-TGIF1-20-AQOR | 20 (40 μL) | 200 μL |
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| ANKRD11-TGIF1-20-AQGO | 20 (40 μL) | 200 μL |
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| ANKRD11-TGIF1-20-AQGR | 20 (40 μL) | 200 μL |
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| ANKRD11-TGIF1-20-AQAQ | 20 (40 μL) | 200 μL |
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TGIF1 Gene Summary
The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provided by RefSeq, Jul 2013]
Gene Name: TGFB Induced Factor Homeobox 1
Chromosome: CHR18: 3412071 -3458406
Locus: 18p11.31
ANKRD11 Gene Summary
This locus encodes an ankryin repeat domain-containing protein. The encoded protein inhibits ligand-dependent activation of transcription. Mutations in this gene have been associated with KBG syndrome, which is characterized by macrodontia, distinctive craniofacial features, short stature, skeletal anomalies, global developmental delay, seizures and intellectual disability. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 2 and X. [provided by RefSeq, Jan 2012]
Gene Name: Ankyrin Repeat Domain 11
Chromosome: CHR16: 89334034 -89556969
Locus: 16q24.3
Gene Diseases
The ANKRD11 TGIF1 Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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