ANXA6-UTRN Fusion FISH Probe
The ANXA6-UTRN Fusion FISH Probe is used to confirm a fusion of the ANXA6 and UTRN genes. The fusion of the ANXA6 and UTRN genes has been associated with Lung Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ANXA6-UTRN-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ANXA6-UTRN-20-RERE | 20 (40 μL) | 200 μL |
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| ANXA6-UTRN-20-REOR | 20 (40 μL) | 200 μL |
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| ANXA6-UTRN-20-REGO | 20 (40 μL) | 200 μL |
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| ANXA6-UTRN-20-REGR | 20 (40 μL) | 200 μL |
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| ANXA6-UTRN-20-REAQ | 20 (40 μL) | 200 μL |
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| ANXA6-UTRN-20-ORRE | 20 (40 μL) | 200 μL |
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| ANXA6-UTRN-20-OROR | 20 (40 μL) | 200 μL |
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| ANXA6-UTRN-20-ORGO | 20 (40 μL) | 200 μL |
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| ANXA6-UTRN-20-ORAQ | 20 (40 μL) | 200 μL |
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| ANXA6-UTRN-20-GORE | 20 (40 μL) | 200 μL |
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| ANXA6-UTRN-20-GOOR | 20 (40 μL) | 200 μL |
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| ANXA6-UTRN-20-GOGO | 20 (40 μL) | 200 μL |
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| ANXA6-UTRN-20-GOGR | 20 (40 μL) | 200 μL |
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| ANXA6-UTRN-20-GOAQ | 20 (40 μL) | 200 μL |
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| ANXA6-UTRN-20-GRRE | 20 (40 μL) | 200 μL |
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| ANXA6-UTRN-20-GROR | 20 (40 μL) | 200 μL |
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| ANXA6-UTRN-20-GRGO | 20 (40 μL) | 200 μL |
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| ANXA6-UTRN-20-GRGR | 20 (40 μL) | 200 μL |
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| ANXA6-UTRN-20-GRAQ | 20 (40 μL) | 200 μL |
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| ANXA6-UTRN-20-AQRE | 20 (40 μL) | 200 μL |
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| ANXA6-UTRN-20-AQOR | 20 (40 μL) | 200 μL |
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| ANXA6-UTRN-20-AQGO | 20 (40 μL) | 200 μL |
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| ANXA6-UTRN-20-AQGR | 20 (40 μL) | 200 μL |
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| ANXA6-UTRN-20-AQAQ | 20 (40 μL) | 200 μL |
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ANXA6 Gene Summary
Annexin VI belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. The annexin VI gene is approximately 60 kbp long and contains 26 exons. It encodes a protein of about 68 kDa that consists of eight 68-amino acid repeats separated by linking sequences of variable lengths. It is highly similar to human annexins I and II sequences, each of which contain four such repeats. Annexin VI has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Aug 2010]
Gene Name: Annexin A6
Chromosome: CHR5: 150480266 -150537443
Locus: 5q33.1
UTRN Gene Summary
This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008]
Gene Name: Utrophin
Chromosome: CHR6: 144612872 -145174170
Locus: 6q24.2
Gene Diseases
The ANXA6 UTRN Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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