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AP2A2-TSPAN4 Fusion FISH Probe

The AP2A2-TSPAN4 Fusion FISH Probe is used to confirm a fusion of the AP2A2 and TSPAN4 genes. The fusion of the AP2A2 and TSPAN4 genes has been associated with Bladder Urothelial Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
AP2A2-TSPAN4-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
AP2A2-TSPAN4-20-RERE 20 (40 μL) 200 μL
AP2A2-TSPAN4-20-REOR 20 (40 μL) 200 μL
AP2A2-TSPAN4-20-REGO 20 (40 μL) 200 μL
AP2A2-TSPAN4-20-REGR 20 (40 μL) 200 μL
AP2A2-TSPAN4-20-REAQ 20 (40 μL) 200 μL
AP2A2-TSPAN4-20-ORRE 20 (40 μL) 200 μL
AP2A2-TSPAN4-20-OROR 20 (40 μL) 200 μL
AP2A2-TSPAN4-20-ORGO 20 (40 μL) 200 μL
AP2A2-TSPAN4-20-ORAQ 20 (40 μL) 200 μL
AP2A2-TSPAN4-20-GORE 20 (40 μL) 200 μL
AP2A2-TSPAN4-20-GOOR 20 (40 μL) 200 μL
AP2A2-TSPAN4-20-GOGO 20 (40 μL) 200 μL
AP2A2-TSPAN4-20-GOGR 20 (40 μL) 200 μL
AP2A2-TSPAN4-20-GOAQ 20 (40 μL) 200 μL
AP2A2-TSPAN4-20-GRRE 20 (40 μL) 200 μL
AP2A2-TSPAN4-20-GROR 20 (40 μL) 200 μL
AP2A2-TSPAN4-20-GRGO 20 (40 μL) 200 μL
AP2A2-TSPAN4-20-GRGR 20 (40 μL) 200 μL
AP2A2-TSPAN4-20-GRAQ 20 (40 μL) 200 μL
AP2A2-TSPAN4-20-AQRE 20 (40 μL) 200 μL
AP2A2-TSPAN4-20-AQOR 20 (40 μL) 200 μL
AP2A2-TSPAN4-20-AQGO 20 (40 μL) 200 μL
AP2A2-TSPAN4-20-AQGR 20 (40 μL) 200 μL
AP2A2-TSPAN4-20-AQAQ 20 (40 μL) 200 μL

AP2A2 Gene Summary

The protein encoded by this gene is a subunit of the AP-2 adaptor protein complex, which is involved in linking lipid and protein membrane components with the clathrin lattice. This interaction supports the formation of clathrin-coated vesicles, and the encoded subunit aids in the process by binding polyphosphoinositide-containing lipids in the cell membrane. [provided by RefSeq, Nov 2016]

Gene Name: Adaptor Related Protein Complex 2 Alpha 2 Subunit

Chromosome: CHR11: 925808 -1012245

Locus: 11p15.5

TSPAN4 Gene Summary

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein and is similar in sequence to its family member CD53 antigen. It is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

Gene Name: Tetraspanin 4

Chromosome: CHR11: 842823 -867116

Locus: 11p15.5

Gene Diseases

The AP2A2 TSPAN4 Fusion has been associated with the following diseases:

Disease Name
Bladder Urothelial Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.