APBA2-OCA2 Fusion FISH Probe
The APBA2-OCA2 Fusion FISH Probe is used to confirm a fusion of the APBA2 and OCA2 genes. The fusion of the APBA2 and OCA2 genes has been associated with Mesothelioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| APBA2-OCA2-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| APBA2-OCA2-20-RERE | 20 (40 μL) | 200 μL |
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| APBA2-OCA2-20-REOR | 20 (40 μL) | 200 μL |
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| APBA2-OCA2-20-REGO | 20 (40 μL) | 200 μL |
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| APBA2-OCA2-20-REGR | 20 (40 μL) | 200 μL |
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| APBA2-OCA2-20-REAQ | 20 (40 μL) | 200 μL |
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| APBA2-OCA2-20-ORRE | 20 (40 μL) | 200 μL |
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| APBA2-OCA2-20-OROR | 20 (40 μL) | 200 μL |
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| APBA2-OCA2-20-ORGO | 20 (40 μL) | 200 μL |
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| APBA2-OCA2-20-ORAQ | 20 (40 μL) | 200 μL |
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| APBA2-OCA2-20-GORE | 20 (40 μL) | 200 μL |
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| APBA2-OCA2-20-GOOR | 20 (40 μL) | 200 μL |
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| APBA2-OCA2-20-GOGO | 20 (40 μL) | 200 μL |
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| APBA2-OCA2-20-GOGR | 20 (40 μL) | 200 μL |
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| APBA2-OCA2-20-GOAQ | 20 (40 μL) | 200 μL |
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| APBA2-OCA2-20-GRRE | 20 (40 μL) | 200 μL |
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| APBA2-OCA2-20-GROR | 20 (40 μL) | 200 μL |
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| APBA2-OCA2-20-GRGO | 20 (40 μL) | 200 μL |
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| APBA2-OCA2-20-GRGR | 20 (40 μL) | 200 μL |
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| APBA2-OCA2-20-GRAQ | 20 (40 μL) | 200 μL |
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| APBA2-OCA2-20-AQRE | 20 (40 μL) | 200 μL |
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| APBA2-OCA2-20-AQOR | 20 (40 μL) | 200 μL |
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| APBA2-OCA2-20-AQGO | 20 (40 μL) | 200 μL |
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| APBA2-OCA2-20-AQGR | 20 (40 μL) | 200 μL |
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| APBA2-OCA2-20-AQAQ | 20 (40 μL) | 200 μL |
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APBA2 Gene Summary
The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. [provided by RefSeq, Jul 2017]
Gene Name: Amyloid Beta Precursor Protein Binding Family A Member 2
Chromosome: CHR15: 29213839 -29410516
Locus: 15q13.1
OCA2 Gene Summary
This gene encodes the human homolog of the mouse p (pink-eyed dilution) gene. The encoded protein is believed to be an integral membrane protein involved in small molecule transport, specifically tyrosine, which is a precursor to melanin synthesis. It is involved in mammalian pigmentation, where it may control skin color variation and act as a determinant of brown or blue eye color. Mutations in this gene result in type 2 oculocutaneous albinism. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Gene Name: OCA2 Melanosomal Transmembrane Protein
Chromosome: CHR15: 28000022 -28344458
Locus: 15q12-q13.1
Gene Diseases
The APBA2 OCA2 Fusion has been associated with the following diseases:
| Disease Name |
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| Mesothelioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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