APLP2-PLAT Fusion FISH Probe
The APLP2-PLAT Fusion FISH Probe is used to confirm a fusion of the APLP2 and PLAT genes. The fusion of the APLP2 and PLAT genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| APLP2-PLAT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| APLP2-PLAT-20-RERE | 20 (40 μL) | 200 μL |
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| APLP2-PLAT-20-REOR | 20 (40 μL) | 200 μL |
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| APLP2-PLAT-20-REGO | 20 (40 μL) | 200 μL |
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| APLP2-PLAT-20-REGR | 20 (40 μL) | 200 μL |
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| APLP2-PLAT-20-REAQ | 20 (40 μL) | 200 μL |
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| APLP2-PLAT-20-ORRE | 20 (40 μL) | 200 μL |
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| APLP2-PLAT-20-OROR | 20 (40 μL) | 200 μL |
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| APLP2-PLAT-20-ORGO | 20 (40 μL) | 200 μL |
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| APLP2-PLAT-20-ORAQ | 20 (40 μL) | 200 μL |
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| APLP2-PLAT-20-GORE | 20 (40 μL) | 200 μL |
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| APLP2-PLAT-20-GOOR | 20 (40 μL) | 200 μL |
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| APLP2-PLAT-20-GOGO | 20 (40 μL) | 200 μL |
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| APLP2-PLAT-20-GOGR | 20 (40 μL) | 200 μL |
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| APLP2-PLAT-20-GOAQ | 20 (40 μL) | 200 μL |
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| APLP2-PLAT-20-GRRE | 20 (40 μL) | 200 μL |
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| APLP2-PLAT-20-GROR | 20 (40 μL) | 200 μL |
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| APLP2-PLAT-20-GRGO | 20 (40 μL) | 200 μL |
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| APLP2-PLAT-20-GRGR | 20 (40 μL) | 200 μL |
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| APLP2-PLAT-20-GRAQ | 20 (40 μL) | 200 μL |
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| APLP2-PLAT-20-AQRE | 20 (40 μL) | 200 μL |
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| APLP2-PLAT-20-AQOR | 20 (40 μL) | 200 μL |
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| APLP2-PLAT-20-AQGO | 20 (40 μL) | 200 μL |
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| APLP2-PLAT-20-AQGR | 20 (40 μL) | 200 μL |
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| APLP2-PLAT-20-AQAQ | 20 (40 μL) | 200 μL |
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APLP2 Gene Summary
This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Gene Name: Amyloid Beta Precursor Like Protein 2
Chromosome: CHR11: 129939715 -130014706
Locus: 11q24.3
PLAT Gene Summary
This gene encodes tissue-type plasminogen activator, a secreted serine protease that converts the proenzyme plasminogen to plasmin, a fibrinolytic enzyme. The encoded preproprotein is proteolytically processed by plasmin or trypsin to generate heavy and light chains. These chains associate via disulfide linkages to form the heterodimeric enzyme. This enzyme plays a role in cell migration and tissue remodeling. Increased enzymatic activity causes hyperfibrinolysis, which manifests as excessive bleeding, while decreased activity leads to hypofibrinolysis, which can result in thrombosis or embolism. Alternative splicing of this gene results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed. [provided by RefSeq, Jan 2016]
Gene Name: Plasminogen Activator, Tissue Type
Chromosome: CHR8: 42032235 -42065194
Locus: 8p11.21
Gene Diseases
The APLP2 PLAT Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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