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APLP2-PLEKHA5 Fusion FISH Probe

The APLP2-PLEKHA5 Fusion FISH Probe is used to confirm a fusion of the APLP2 and PLEKHA5 genes. The fusion of the APLP2 and PLEKHA5 genes has been associated with Kidney Renal Clear Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
APLP2-PLEKHA5-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
APLP2-PLEKHA5-20-RERE 20 (40 μL) 200 μL
APLP2-PLEKHA5-20-REOR 20 (40 μL) 200 μL
APLP2-PLEKHA5-20-REGO 20 (40 μL) 200 μL
APLP2-PLEKHA5-20-REGR 20 (40 μL) 200 μL
APLP2-PLEKHA5-20-REAQ 20 (40 μL) 200 μL
APLP2-PLEKHA5-20-ORRE 20 (40 μL) 200 μL
APLP2-PLEKHA5-20-OROR 20 (40 μL) 200 μL
APLP2-PLEKHA5-20-ORGO 20 (40 μL) 200 μL
APLP2-PLEKHA5-20-ORAQ 20 (40 μL) 200 μL
APLP2-PLEKHA5-20-GORE 20 (40 μL) 200 μL
APLP2-PLEKHA5-20-GOOR 20 (40 μL) 200 μL
APLP2-PLEKHA5-20-GOGO 20 (40 μL) 200 μL
APLP2-PLEKHA5-20-GOGR 20 (40 μL) 200 μL
APLP2-PLEKHA5-20-GOAQ 20 (40 μL) 200 μL
APLP2-PLEKHA5-20-GRRE 20 (40 μL) 200 μL
APLP2-PLEKHA5-20-GROR 20 (40 μL) 200 μL
APLP2-PLEKHA5-20-GRGO 20 (40 μL) 200 μL
APLP2-PLEKHA5-20-GRGR 20 (40 μL) 200 μL
APLP2-PLEKHA5-20-GRAQ 20 (40 μL) 200 μL
APLP2-PLEKHA5-20-AQRE 20 (40 μL) 200 μL
APLP2-PLEKHA5-20-AQOR 20 (40 μL) 200 μL
APLP2-PLEKHA5-20-AQGO 20 (40 μL) 200 μL
APLP2-PLEKHA5-20-AQGR 20 (40 μL) 200 μL
APLP2-PLEKHA5-20-AQAQ 20 (40 μL) 200 μL

APLP2 Gene Summary

This gene encodes amyloid precursor- like protein 2 (APLP2), which is a member of the APP (amyloid precursor protein) family including APP, APLP1 and APLP2. This protein is ubiquitously expressed. It contains heparin-, copper- and zinc- binding domains at the N-terminus, BPTI/Kunitz inhibitor and E2 domains in the middle region, and transmembrane and intracellular domains at the C-terminus. This protein interacts with major histocompatibility complex (MHC) class I molecules. The synergy of this protein and the APP is required to mediate neuromuscular transmission, spatial learning and synaptic plasticity. This protein has been implicated in the pathogenesis of Alzheimer's disease. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Gene Name: Amyloid Beta Precursor Like Protein 2

Chromosome: CHR11: 129939715 -130014706

Locus: 11q24.3

PLEKHA5 Gene Summary

The Pleckstrin Homology Domain Containing A5 (PLEKHA5) gene is located on chr12 :19282625-19529333 at 12p12.3.

Gene Name: Pleckstrin Homology Domain Containing A5

Chromosome: CHR12: 19282625 -19529333

Locus: 12p12.3

Gene Diseases

The APLP2 PLEKHA5 Fusion has been associated with the following diseases:

Disease Name
Kidney Renal Clear Cell Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.