APP-EEA1 Fusion FISH Probe
The APP-EEA1 Fusion FISH Probe is used to confirm a fusion of the APP and EEA1 genes. The fusion of the APP and EEA1 genes has been associated with Brain Lower Grade Glioma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| APP-EEA1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| APP-EEA1-20-RERE | 20 (40 μL) | 200 μL |
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| APP-EEA1-20-REOR | 20 (40 μL) | 200 μL |
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| APP-EEA1-20-REGO | 20 (40 μL) | 200 μL |
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| APP-EEA1-20-REGR | 20 (40 μL) | 200 μL |
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| APP-EEA1-20-REAQ | 20 (40 μL) | 200 μL |
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| APP-EEA1-20-ORRE | 20 (40 μL) | 200 μL |
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| APP-EEA1-20-OROR | 20 (40 μL) | 200 μL |
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| APP-EEA1-20-ORGO | 20 (40 μL) | 200 μL |
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| APP-EEA1-20-ORAQ | 20 (40 μL) | 200 μL |
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| APP-EEA1-20-GORE | 20 (40 μL) | 200 μL |
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| APP-EEA1-20-GOOR | 20 (40 μL) | 200 μL |
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| APP-EEA1-20-GOGO | 20 (40 μL) | 200 μL |
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| APP-EEA1-20-GOGR | 20 (40 μL) | 200 μL |
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| APP-EEA1-20-GOAQ | 20 (40 μL) | 200 μL |
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| APP-EEA1-20-GRRE | 20 (40 μL) | 200 μL |
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| APP-EEA1-20-GROR | 20 (40 μL) | 200 μL |
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| APP-EEA1-20-GRGO | 20 (40 μL) | 200 μL |
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| APP-EEA1-20-GRGR | 20 (40 μL) | 200 μL |
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| APP-EEA1-20-GRAQ | 20 (40 μL) | 200 μL |
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| APP-EEA1-20-AQRE | 20 (40 μL) | 200 μL |
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| APP-EEA1-20-AQOR | 20 (40 μL) | 200 μL |
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| APP-EEA1-20-AQGO | 20 (40 μL) | 200 μL |
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| APP-EEA1-20-AQGR | 20 (40 μL) | 200 μL |
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| APP-EEA1-20-AQAQ | 20 (40 μL) | 200 μL |
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APP Gene Summary
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]
Gene Name: Amyloid Beta Precursor Protein
Chromosome: CHR21: 27252860 -27543446
Locus: 21q21.3
EEA1 Gene Summary
The Early Endosome Antigen 1 (EEA1) gene is located on chr12 :93166284-93323107 at 12q22.
Gene Name: Early Endosome Antigen 1
Chromosome: CHR12: 93166284 -93323107
Locus: 12q22
Gene Diseases
The APP EEA1 Fusion has been associated with the following diseases:
| Disease Name |
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| Brain Lower Grade Glioma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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