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APP-SEC63 Fusion FISH Probe

The APP-SEC63 Fusion FISH Probe is used to confirm a fusion of the APP and SEC63 genes. The fusion of the APP and SEC63 genes has been associated with Thyroid Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.

** This product is for in vitro and research use only. This product is not intended for diagnostic use.

Turnaround Time: 7-10 Business Days    Shipping Time: 1-2 Day Expedited Shipping

SKU Test Kits Buffer Dye Color Order Now
APP-SEC63-20-ORGR  (Standard Design) 20 (40 μL) 200 μL
APP-SEC63-20-RERE 20 (40 μL) 200 μL
APP-SEC63-20-REOR 20 (40 μL) 200 μL
APP-SEC63-20-REGO 20 (40 μL) 200 μL
APP-SEC63-20-REGR 20 (40 μL) 200 μL
APP-SEC63-20-REAQ 20 (40 μL) 200 μL
APP-SEC63-20-ORRE 20 (40 μL) 200 μL
APP-SEC63-20-OROR 20 (40 μL) 200 μL
APP-SEC63-20-ORGO 20 (40 μL) 200 μL
APP-SEC63-20-ORAQ 20 (40 μL) 200 μL
APP-SEC63-20-GORE 20 (40 μL) 200 μL
APP-SEC63-20-GOOR 20 (40 μL) 200 μL
APP-SEC63-20-GOGO 20 (40 μL) 200 μL
APP-SEC63-20-GOGR 20 (40 μL) 200 μL
APP-SEC63-20-GOAQ 20 (40 μL) 200 μL
APP-SEC63-20-GRRE 20 (40 μL) 200 μL
APP-SEC63-20-GROR 20 (40 μL) 200 μL
APP-SEC63-20-GRGO 20 (40 μL) 200 μL
APP-SEC63-20-GRGR 20 (40 μL) 200 μL
APP-SEC63-20-GRAQ 20 (40 μL) 200 μL
APP-SEC63-20-AQRE 20 (40 μL) 200 μL
APP-SEC63-20-AQOR 20 (40 μL) 200 μL
APP-SEC63-20-AQGO 20 (40 μL) 200 μL
APP-SEC63-20-AQGR 20 (40 μL) 200 μL
APP-SEC63-20-AQAQ 20 (40 μL) 200 μL

APP Gene Summary

This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]

Gene Name: Amyloid Beta Precursor Protein

Chromosome: CHR21: 27252860 -27543446

Locus: 21q21.3

SEC63 Gene Summary

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The protein encoded by this gene and SEC62 protein are found to be associated with ribosome-free SEC61 complex. It is speculated that Sec61-Sec62-Sec63 may perform post-translational protein translocation into the ER. The Sec61-Sec62-Sec63 complex might also perform the backward transport of ER proteins that are subject to the ubiquitin-proteasome-dependent degradation pathway. The encoded protein is an integral membrane protein located in the rough ER. [provided by RefSeq, Jul 2008]

Gene Name: SEC63 Homolog, Protein Translocation Regulator

Chromosome: CHR6: 108188959 -108279482

Locus: 6q21

Gene Diseases

The APP SEC63 Fusion has been associated with the following diseases:

Disease Name
Thyroid Carcinoma

FISH Probe Protocols

Protocol, Procedure, or Form Name Last Modified Download

Customer Publications

There are currently no FISH related publications for this probe.