APPL2-CIT Fusion FISH Probe
The APPL2-CIT Fusion FISH Probe is used to confirm a fusion of the APPL2 and CIT genes. The fusion of the APPL2 and CIT genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| APPL2-CIT-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| APPL2-CIT-20-RERE | 20 (40 μL) | 200 μL |
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| APPL2-CIT-20-REOR | 20 (40 μL) | 200 μL |
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| APPL2-CIT-20-REGO | 20 (40 μL) | 200 μL |
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| APPL2-CIT-20-REGR | 20 (40 μL) | 200 μL |
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| APPL2-CIT-20-REAQ | 20 (40 μL) | 200 μL |
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| APPL2-CIT-20-ORRE | 20 (40 μL) | 200 μL |
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| APPL2-CIT-20-OROR | 20 (40 μL) | 200 μL |
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| APPL2-CIT-20-ORGO | 20 (40 μL) | 200 μL |
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| APPL2-CIT-20-ORAQ | 20 (40 μL) | 200 μL |
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| APPL2-CIT-20-GORE | 20 (40 μL) | 200 μL |
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| APPL2-CIT-20-GOOR | 20 (40 μL) | 200 μL |
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| APPL2-CIT-20-GOGO | 20 (40 μL) | 200 μL |
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| APPL2-CIT-20-GOGR | 20 (40 μL) | 200 μL |
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| APPL2-CIT-20-GOAQ | 20 (40 μL) | 200 μL |
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| APPL2-CIT-20-GRRE | 20 (40 μL) | 200 μL |
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| APPL2-CIT-20-GROR | 20 (40 μL) | 200 μL |
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| APPL2-CIT-20-GRGO | 20 (40 μL) | 200 μL |
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| APPL2-CIT-20-GRGR | 20 (40 μL) | 200 μL |
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| APPL2-CIT-20-GRAQ | 20 (40 μL) | 200 μL |
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| APPL2-CIT-20-AQRE | 20 (40 μL) | 200 μL |
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| APPL2-CIT-20-AQOR | 20 (40 μL) | 200 μL |
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| APPL2-CIT-20-AQGO | 20 (40 μL) | 200 μL |
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| APPL2-CIT-20-AQGR | 20 (40 μL) | 200 μL |
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| APPL2-CIT-20-AQAQ | 20 (40 μL) | 200 μL |
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CIT Gene Summary
This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Gene Name: Citron Rho-interacting Serine/threonine Kinase
Chromosome: CHR12: 120123594 -120315095
Locus: 12q24.23
APPL2 Gene Summary
The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12;22)(q24.1;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome. [provided by RefSeq, Oct 2011]
Gene Name: Adaptor Protein, Phosphotyrosine Interacting With PH Domain And Leucine Zipper 2
Chromosome: CHR12: 105567074 -105630008
Locus: 12q23.3
Gene Diseases
The APPL2 CIT Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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