APTX-GNE Fusion FISH Probe
The APTX-GNE Fusion FISH Probe is used to confirm a fusion of the APTX and GNE genes. The fusion of the APTX and GNE genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| APTX-GNE-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| APTX-GNE-20-RERE | 20 (40 μL) | 200 μL |
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| APTX-GNE-20-REOR | 20 (40 μL) | 200 μL |
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| APTX-GNE-20-REGO | 20 (40 μL) | 200 μL |
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| APTX-GNE-20-REGR | 20 (40 μL) | 200 μL |
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| APTX-GNE-20-REAQ | 20 (40 μL) | 200 μL |
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| APTX-GNE-20-ORRE | 20 (40 μL) | 200 μL |
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| APTX-GNE-20-OROR | 20 (40 μL) | 200 μL |
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| APTX-GNE-20-ORGO | 20 (40 μL) | 200 μL |
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| APTX-GNE-20-ORAQ | 20 (40 μL) | 200 μL |
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| APTX-GNE-20-GORE | 20 (40 μL) | 200 μL |
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| APTX-GNE-20-GOOR | 20 (40 μL) | 200 μL |
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| APTX-GNE-20-GOGO | 20 (40 μL) | 200 μL |
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| APTX-GNE-20-GOGR | 20 (40 μL) | 200 μL |
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| APTX-GNE-20-GOAQ | 20 (40 μL) | 200 μL |
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| APTX-GNE-20-GRRE | 20 (40 μL) | 200 μL |
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| APTX-GNE-20-GROR | 20 (40 μL) | 200 μL |
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| APTX-GNE-20-GRGO | 20 (40 μL) | 200 μL |
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| APTX-GNE-20-GRGR | 20 (40 μL) | 200 μL |
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| APTX-GNE-20-GRAQ | 20 (40 μL) | 200 μL |
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| APTX-GNE-20-AQRE | 20 (40 μL) | 200 μL |
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| APTX-GNE-20-AQOR | 20 (40 μL) | 200 μL |
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| APTX-GNE-20-AQGO | 20 (40 μL) | 200 μL |
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| APTX-GNE-20-AQGR | 20 (40 μL) | 200 μL |
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| APTX-GNE-20-AQAQ | 20 (40 μL) | 200 μL |
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GNE Gene Summary
The protein encoded by this gene is a bifunctional enzyme that initiates and regulates the biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It is a rate-limiting enzyme in the sialic acid biosynthetic pathway. Sialic acid modification of cell surface molecules is crucial for their function in many biologic processes, including cell adhesion and signal transduction. Differential sialylation of cell surface molecules is also implicated in the tumorigenicity and metastatic behavior of malignant cells. Mutations in this gene are associated with sialuria, autosomal recessive inclusion body myopathy, and Nonaka myopathy. Alternative splicing of this gene results in transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Gene Name: Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine Kinase
Chromosome: CHR9: 36214438 -36277053
Locus: 9p13.3
APTX Gene Summary
This gene encodes a member of the histidine triad (HIT) superfamily. The encoded protein may play a role in single-stranded DNA repair through its nucleotide-binding activity and its diadenosine polyphosphate hydrolase activity. Mutations in this gene have been associated with ataxia-ocular apraxia. Alternatively spliced transcript variants have been identified for this gene.[provided by RefSeq, Aug 2010]
Gene Name: Aprataxin
Chromosome: CHR9: 32972603 -33001639
Locus: 9p21.1
Gene Diseases
The APTX GNE Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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