ARAP1-USP35 Fusion FISH Probe
The ARAP1-USP35 Fusion FISH Probe is used to confirm a fusion of the ARAP1 and USP35 genes. The fusion of the ARAP1 and USP35 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ARAP1-USP35-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ARAP1-USP35-20-RERE | 20 (40 μL) | 200 μL |
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| ARAP1-USP35-20-REOR | 20 (40 μL) | 200 μL |
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| ARAP1-USP35-20-REGO | 20 (40 μL) | 200 μL |
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| ARAP1-USP35-20-REGR | 20 (40 μL) | 200 μL |
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| ARAP1-USP35-20-REAQ | 20 (40 μL) | 200 μL |
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| ARAP1-USP35-20-ORRE | 20 (40 μL) | 200 μL |
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| ARAP1-USP35-20-OROR | 20 (40 μL) | 200 μL |
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| ARAP1-USP35-20-ORGO | 20 (40 μL) | 200 μL |
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| ARAP1-USP35-20-ORAQ | 20 (40 μL) | 200 μL |
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| ARAP1-USP35-20-GORE | 20 (40 μL) | 200 μL |
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| ARAP1-USP35-20-GOOR | 20 (40 μL) | 200 μL |
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| ARAP1-USP35-20-GOGO | 20 (40 μL) | 200 μL |
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| ARAP1-USP35-20-GOGR | 20 (40 μL) | 200 μL |
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| ARAP1-USP35-20-GOAQ | 20 (40 μL) | 200 μL |
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| ARAP1-USP35-20-GRRE | 20 (40 μL) | 200 μL |
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| ARAP1-USP35-20-GROR | 20 (40 μL) | 200 μL |
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| ARAP1-USP35-20-GRGO | 20 (40 μL) | 200 μL |
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| ARAP1-USP35-20-GRGR | 20 (40 μL) | 200 μL |
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| ARAP1-USP35-20-GRAQ | 20 (40 μL) | 200 μL |
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| ARAP1-USP35-20-AQRE | 20 (40 μL) | 200 μL |
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| ARAP1-USP35-20-AQOR | 20 (40 μL) | 200 μL |
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| ARAP1-USP35-20-AQGO | 20 (40 μL) | 200 μL |
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| ARAP1-USP35-20-AQGR | 20 (40 μL) | 200 μL |
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| ARAP1-USP35-20-AQAQ | 20 (40 μL) | 200 μL |
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USP35 Gene Summary
This gene encodes a member of the peptidase C19 family of ubiquitin-specific proteases. These deubiquitinating enzymes (DUBs) catalyze the removal of ubiquitin proteins from other proteins. The encoded protein associates with polarized mitochondria and has been shown to inhibit NF-kappa B activation and delay PARK2-mediated degradation of mitochondria. Expression of this gene is upregulated by the let-7a microRNA and reduced expression has been observed in human tumor tissues. [provided by RefSeq, Jul 2017]
Gene Name: Ubiquitin Specific Peptidase 35
Chromosome: CHR11: 77899857 -77925757
Locus: 11q14.1
ARAP1 Gene Summary
The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Gene Name: ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 1
Chromosome: CHR11: 72396113 -72463434
Locus: 11q13.4
Gene Diseases
The ARAP1 USP35 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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