ARAP2-PDS5A Fusion FISH Probe
The ARAP2-PDS5A Fusion FISH Probe is used to confirm a fusion of the ARAP2 and PDS5A genes. The fusion of the ARAP2 and PDS5A genes has been associated with Lung Squamous Cell Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ARAP2-PDS5A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ARAP2-PDS5A-20-RERE | 20 (40 μL) | 200 μL |
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| ARAP2-PDS5A-20-REOR | 20 (40 μL) | 200 μL |
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| ARAP2-PDS5A-20-REGO | 20 (40 μL) | 200 μL |
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| ARAP2-PDS5A-20-REGR | 20 (40 μL) | 200 μL |
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| ARAP2-PDS5A-20-REAQ | 20 (40 μL) | 200 μL |
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| ARAP2-PDS5A-20-ORRE | 20 (40 μL) | 200 μL |
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| ARAP2-PDS5A-20-OROR | 20 (40 μL) | 200 μL |
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| ARAP2-PDS5A-20-ORGO | 20 (40 μL) | 200 μL |
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| ARAP2-PDS5A-20-ORAQ | 20 (40 μL) | 200 μL |
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| ARAP2-PDS5A-20-GORE | 20 (40 μL) | 200 μL |
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| ARAP2-PDS5A-20-GOOR | 20 (40 μL) | 200 μL |
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| ARAP2-PDS5A-20-GOGO | 20 (40 μL) | 200 μL |
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| ARAP2-PDS5A-20-GOGR | 20 (40 μL) | 200 μL |
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| ARAP2-PDS5A-20-GOAQ | 20 (40 μL) | 200 μL |
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| ARAP2-PDS5A-20-GRRE | 20 (40 μL) | 200 μL |
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| ARAP2-PDS5A-20-GROR | 20 (40 μL) | 200 μL |
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| ARAP2-PDS5A-20-GRGO | 20 (40 μL) | 200 μL |
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| ARAP2-PDS5A-20-GRGR | 20 (40 μL) | 200 μL |
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| ARAP2-PDS5A-20-GRAQ | 20 (40 μL) | 200 μL |
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| ARAP2-PDS5A-20-AQRE | 20 (40 μL) | 200 μL |
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| ARAP2-PDS5A-20-AQOR | 20 (40 μL) | 200 μL |
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| ARAP2-PDS5A-20-AQGO | 20 (40 μL) | 200 μL |
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| ARAP2-PDS5A-20-AQGR | 20 (40 μL) | 200 μL |
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| ARAP2-PDS5A-20-AQAQ | 20 (40 μL) | 200 μL |
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PDS5A Gene Summary
The protein encoded by this gene binds to the cohesin complex and associates with chromatin through most of the cell cycle. The encoded protein may play a role in regulating sister chromatid cohesion during mitosis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]
Gene Name: PDS5 Cohesin Associated Factor A
Chromosome: CHR4: 39824482 -39979576
Locus: 4p14
ARAP2 Gene Summary
The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. The protein is a phosphatidylinositol (3,4,5)-trisphosphate-dependent Arf6 GAP that binds RhoA-GTP, but it lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. The protein associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. [provided by RefSeq, Sep 2008]
Gene Name: ArfGAP With RhoGAP Domain, Ankyrin Repeat And PH Domain 2
Chromosome: CHR4: 36067619 -36245979
Locus: 4p14
Gene Diseases
The ARAP2 PDS5A Fusion has been associated with the following diseases:
| Disease Name |
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| Lung Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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