ARFGAP1-SPAG4 Fusion FISH Probe
The ARFGAP1-SPAG4 Fusion FISH Probe is used to confirm a fusion of the ARFGAP1 and SPAG4 genes. The fusion of the ARFGAP1 and SPAG4 genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ARFGAP1-SPAG4-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ARFGAP1-SPAG4-20-RERE | 20 (40 μL) | 200 μL |
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| ARFGAP1-SPAG4-20-REOR | 20 (40 μL) | 200 μL |
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| ARFGAP1-SPAG4-20-REGO | 20 (40 μL) | 200 μL |
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| ARFGAP1-SPAG4-20-REGR | 20 (40 μL) | 200 μL |
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| ARFGAP1-SPAG4-20-REAQ | 20 (40 μL) | 200 μL |
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| ARFGAP1-SPAG4-20-ORRE | 20 (40 μL) | 200 μL |
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| ARFGAP1-SPAG4-20-OROR | 20 (40 μL) | 200 μL |
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| ARFGAP1-SPAG4-20-ORGO | 20 (40 μL) | 200 μL |
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| ARFGAP1-SPAG4-20-ORAQ | 20 (40 μL) | 200 μL |
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| ARFGAP1-SPAG4-20-GORE | 20 (40 μL) | 200 μL |
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| ARFGAP1-SPAG4-20-GOOR | 20 (40 μL) | 200 μL |
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| ARFGAP1-SPAG4-20-GOGO | 20 (40 μL) | 200 μL |
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| ARFGAP1-SPAG4-20-GOGR | 20 (40 μL) | 200 μL |
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| ARFGAP1-SPAG4-20-GOAQ | 20 (40 μL) | 200 μL |
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| ARFGAP1-SPAG4-20-GRRE | 20 (40 μL) | 200 μL |
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| ARFGAP1-SPAG4-20-GROR | 20 (40 μL) | 200 μL |
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| ARFGAP1-SPAG4-20-GRGO | 20 (40 μL) | 200 μL |
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| ARFGAP1-SPAG4-20-GRGR | 20 (40 μL) | 200 μL |
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| ARFGAP1-SPAG4-20-GRAQ | 20 (40 μL) | 200 μL |
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| ARFGAP1-SPAG4-20-AQRE | 20 (40 μL) | 200 μL |
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| ARFGAP1-SPAG4-20-AQOR | 20 (40 μL) | 200 μL |
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| ARFGAP1-SPAG4-20-AQGO | 20 (40 μL) | 200 μL |
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| ARFGAP1-SPAG4-20-AQGR | 20 (40 μL) | 200 μL |
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| ARFGAP1-SPAG4-20-AQAQ | 20 (40 μL) | 200 μL |
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SPAG4 Gene Summary
The mammalian sperm flagellum contains two cytoskeletal structures associated with the axoneme: the outer dense fibers surrounding the axoneme in the midpiece and principal piece and the fibrous sheath surrounding the outer dense fibers in the principal piece of the tail. Defects in these structures are associated with abnormal tail morphology, reduced sperm motility, and infertility. In the rat, the protein encoded by this gene associates with an outer dense fiber protein via a leucine zipper motif and localizes to the microtubules of the manchette and axoneme during sperm tail development. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Gene Name: Sperm Associated Antigen 4
Chromosome: CHR20: 34203808 -34208965
Locus: 20q11.22
ARFGAP1 Gene Summary
The protein encoded by this gene is a GTPase-activating protein, which associates with the Golgi apparatus and which interacts with ADP-ribosylation factor 1. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1-bound GTP and is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is required for the fusion of these vesicles with target compartments. The activity of this protein is stimulated by phosphoinosides and inhibited by phosphatidylcholine. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Gene Name: ADP Ribosylation Factor GTPase Activating Protein 1
Chromosome: CHR20: 61904164 -61921142
Locus: 20q13.33
Gene Diseases
The ARFGAP1 SPAG4 Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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