ARFGAP3-FBLN1 Fusion FISH Probe
The ARFGAP3-FBLN1 Fusion FISH Probe is used to confirm a fusion of the ARFGAP3 and FBLN1 genes. The fusion of the ARFGAP3 and FBLN1 genes has been associated with Skin Cutaneous Melanoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ARFGAP3-FBLN1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ARFGAP3-FBLN1-20-RERE | 20 (40 μL) | 200 μL |
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| ARFGAP3-FBLN1-20-REOR | 20 (40 μL) | 200 μL |
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| ARFGAP3-FBLN1-20-REGO | 20 (40 μL) | 200 μL |
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| ARFGAP3-FBLN1-20-REGR | 20 (40 μL) | 200 μL |
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| ARFGAP3-FBLN1-20-REAQ | 20 (40 μL) | 200 μL |
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| ARFGAP3-FBLN1-20-ORRE | 20 (40 μL) | 200 μL |
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| ARFGAP3-FBLN1-20-OROR | 20 (40 μL) | 200 μL |
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| ARFGAP3-FBLN1-20-ORGO | 20 (40 μL) | 200 μL |
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| ARFGAP3-FBLN1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ARFGAP3-FBLN1-20-GORE | 20 (40 μL) | 200 μL |
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| ARFGAP3-FBLN1-20-GOOR | 20 (40 μL) | 200 μL |
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| ARFGAP3-FBLN1-20-GOGO | 20 (40 μL) | 200 μL |
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| ARFGAP3-FBLN1-20-GOGR | 20 (40 μL) | 200 μL |
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| ARFGAP3-FBLN1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ARFGAP3-FBLN1-20-GRRE | 20 (40 μL) | 200 μL |
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| ARFGAP3-FBLN1-20-GROR | 20 (40 μL) | 200 μL |
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| ARFGAP3-FBLN1-20-GRGO | 20 (40 μL) | 200 μL |
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| ARFGAP3-FBLN1-20-GRGR | 20 (40 μL) | 200 μL |
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| ARFGAP3-FBLN1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ARFGAP3-FBLN1-20-AQRE | 20 (40 μL) | 200 μL |
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| ARFGAP3-FBLN1-20-AQOR | 20 (40 μL) | 200 μL |
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| ARFGAP3-FBLN1-20-AQGO | 20 (40 μL) | 200 μL |
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| ARFGAP3-FBLN1-20-AQGR | 20 (40 μL) | 200 μL |
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| ARFGAP3-FBLN1-20-AQAQ | 20 (40 μL) | 200 μL |
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FBLN1 Gene Summary
Fibulin 1 is a secreted glycoprotein that becomes incorporated into a fibrillar extracellular matrix. Calcium-binding is apparently required to mediate its binding to laminin and nidogen. It mediates platelet adhesion via binding fibrinogen. Four splice variants which differ in the 3' end have been identified. Each variant encodes a different isoform, but no functional distinctions have been identified among the four variants. [provided by RefSeq, Jul 2008]
Gene Name: Fibulin 1
Chromosome: CHR22: 45898718 -45997014
Locus: 22q13.31
ARFGAP3 Gene Summary
The protein encoded by this gene is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and regulates the early secretory pathway of proteins. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1 (ARF1)-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. Multiple transcript variants encoding different isoforms have been found for this gene. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene. [provided by RefSeq, Nov 2008]
Gene Name: ADP Ribosylation Factor GTPase Activating Protein 3
Chromosome: CHR22: 43192531 -43253408
Locus: 22q13.2
Gene Diseases
The ARFGAP3 FBLN1 Fusion has been associated with the following diseases:
| Disease Name |
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| Skin Cutaneous Melanoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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