ARFGEF1-SHC1 Fusion FISH Probe
The ARFGEF1-SHC1 Fusion FISH Probe is used to confirm a fusion of the ARFGEF1 and SHC1 genes. The fusion of the ARFGEF1 and SHC1 genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ARFGEF1-SHC1-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-RERE | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-REOR | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-REGO | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-REGR | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-REAQ | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-ORRE | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-OROR | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-ORGO | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-ORAQ | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-GORE | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-GOOR | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-GOGO | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-GOGR | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-GOAQ | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-GRRE | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-GROR | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-GRGO | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-GRGR | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-GRAQ | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-AQRE | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-AQOR | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-AQGO | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-AQGR | 20 (40 μL) | 200 μL |
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| ARFGEF1-SHC1-20-AQAQ | 20 (40 μL) | 200 μL |
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SHC1 Gene Summary
This gene encodes three main isoforms that differ in activities and subcellular location. While all three are adapter proteins in signal transduction pathways, the longest (p66Shc) may be involved in regulating life span and the effects of reactive oxygen species. The other two isoforms, p52Shc and p46Shc, link activated receptor tyrosine kinases to the Ras pathway by recruitment of the GRB2/SOS complex. p66Shc is not involved in Ras activation. Unlike the other two isoforms, p46Shc is targeted to the mitochondrial matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]
Gene Name: SHC Adaptor Protein 1
Chromosome: CHR1: 154934773 -154946959
Locus: 1q21.3
ARFGEF1 Gene Summary
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Aug 2011]
Gene Name: ADP Ribosylation Factor Guanine Nucleotide Exchange Factor 1
Chromosome: CHR8: 68109883 -68255912
Locus: 8q13.2
Gene Diseases
The ARFGEF1 SHC1 Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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