ARFGEF2-HNF4A Fusion FISH Probe
The ARFGEF2-HNF4A Fusion FISH Probe is used to confirm a fusion of the ARFGEF2 and HNF4A genes. The fusion of the ARFGEF2 and HNF4A genes has been associated with Sarcoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ARFGEF2-HNF4A-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ARFGEF2-HNF4A-20-RERE | 20 (40 μL) | 200 μL |
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| ARFGEF2-HNF4A-20-REOR | 20 (40 μL) | 200 μL |
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| ARFGEF2-HNF4A-20-REGO | 20 (40 μL) | 200 μL |
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| ARFGEF2-HNF4A-20-REGR | 20 (40 μL) | 200 μL |
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| ARFGEF2-HNF4A-20-REAQ | 20 (40 μL) | 200 μL |
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| ARFGEF2-HNF4A-20-ORRE | 20 (40 μL) | 200 μL |
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| ARFGEF2-HNF4A-20-OROR | 20 (40 μL) | 200 μL |
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| ARFGEF2-HNF4A-20-ORGO | 20 (40 μL) | 200 μL |
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| ARFGEF2-HNF4A-20-ORAQ | 20 (40 μL) | 200 μL |
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| ARFGEF2-HNF4A-20-GORE | 20 (40 μL) | 200 μL |
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| ARFGEF2-HNF4A-20-GOOR | 20 (40 μL) | 200 μL |
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| ARFGEF2-HNF4A-20-GOGO | 20 (40 μL) | 200 μL |
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| ARFGEF2-HNF4A-20-GOGR | 20 (40 μL) | 200 μL |
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| ARFGEF2-HNF4A-20-GOAQ | 20 (40 μL) | 200 μL |
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| ARFGEF2-HNF4A-20-GRRE | 20 (40 μL) | 200 μL |
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| ARFGEF2-HNF4A-20-GROR | 20 (40 μL) | 200 μL |
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| ARFGEF2-HNF4A-20-GRGO | 20 (40 μL) | 200 μL |
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| ARFGEF2-HNF4A-20-GRGR | 20 (40 μL) | 200 μL |
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| ARFGEF2-HNF4A-20-GRAQ | 20 (40 μL) | 200 μL |
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| ARFGEF2-HNF4A-20-AQRE | 20 (40 μL) | 200 μL |
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| ARFGEF2-HNF4A-20-AQOR | 20 (40 μL) | 200 μL |
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| ARFGEF2-HNF4A-20-AQGO | 20 (40 μL) | 200 μL |
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| ARFGEF2-HNF4A-20-AQGR | 20 (40 μL) | 200 μL |
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| ARFGEF2-HNF4A-20-AQAQ | 20 (40 μL) | 200 μL |
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HNF4A Gene Summary
The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012]
Gene Name: Hepatocyte Nuclear Factor 4 Alpha
Chromosome: CHR20: 42984440 -43058311
Locus: 20q13.12
ARFGEF2 Gene Summary
ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition. [provided by RefSeq, Jul 2008]
Gene Name: ADP Ribosylation Factor Guanine Nucleotide Exchange Factor 2
Chromosome: CHR20: 47538274 -47653230
Locus: 20q13.13
Gene Diseases
The ARFGEF2 HNF4A Fusion has been associated with the following diseases:
| Disease Name |
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| Sarcoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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