ARHGAP12-SORCS3 Fusion FISH Probe
The ARHGAP12-SORCS3 Fusion FISH Probe is used to confirm a fusion of the ARHGAP12 and SORCS3 genes. The fusion of the ARHGAP12 and SORCS3 genes has been associated with Head And Neck Squamous Cell Carcinoma . These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ARHGAP12-SORCS3-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ARHGAP12-SORCS3-20-RERE | 20 (40 μL) | 200 μL |
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| ARHGAP12-SORCS3-20-REOR | 20 (40 μL) | 200 μL |
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| ARHGAP12-SORCS3-20-REGO | 20 (40 μL) | 200 μL |
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| ARHGAP12-SORCS3-20-REGR | 20 (40 μL) | 200 μL |
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| ARHGAP12-SORCS3-20-REAQ | 20 (40 μL) | 200 μL |
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| ARHGAP12-SORCS3-20-ORRE | 20 (40 μL) | 200 μL |
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| ARHGAP12-SORCS3-20-OROR | 20 (40 μL) | 200 μL |
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| ARHGAP12-SORCS3-20-ORGO | 20 (40 μL) | 200 μL |
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| ARHGAP12-SORCS3-20-ORAQ | 20 (40 μL) | 200 μL |
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| ARHGAP12-SORCS3-20-GORE | 20 (40 μL) | 200 μL |
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| ARHGAP12-SORCS3-20-GOOR | 20 (40 μL) | 200 μL |
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| ARHGAP12-SORCS3-20-GOGO | 20 (40 μL) | 200 μL |
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| ARHGAP12-SORCS3-20-GOGR | 20 (40 μL) | 200 μL |
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| ARHGAP12-SORCS3-20-GOAQ | 20 (40 μL) | 200 μL |
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| ARHGAP12-SORCS3-20-GRRE | 20 (40 μL) | 200 μL |
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| ARHGAP12-SORCS3-20-GROR | 20 (40 μL) | 200 μL |
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| ARHGAP12-SORCS3-20-GRGO | 20 (40 μL) | 200 μL |
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| ARHGAP12-SORCS3-20-GRGR | 20 (40 μL) | 200 μL |
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| ARHGAP12-SORCS3-20-GRAQ | 20 (40 μL) | 200 μL |
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| ARHGAP12-SORCS3-20-AQRE | 20 (40 μL) | 200 μL |
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| ARHGAP12-SORCS3-20-AQOR | 20 (40 μL) | 200 μL |
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| ARHGAP12-SORCS3-20-AQGO | 20 (40 μL) | 200 μL |
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| ARHGAP12-SORCS3-20-AQGR | 20 (40 μL) | 200 μL |
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| ARHGAP12-SORCS3-20-AQAQ | 20 (40 μL) | 200 μL |
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SORCS3 Gene Summary
This gene encodes a type-I receptor transmembrane protein that is a member of the vacuolar protein sorting 10 receptor family. Proteins of this family are defined by a vacuolar protein sorting 10 domain at the N-terminus. The N-terminal segment of this domain has a consensus motif for proprotein convertase processing, and the C-terminal segment of this domain is characterized by ten conserved cysteine residues. The vacuolar protein sorting 10 domain is followed by a leucine-rich segment, a transmembrane domain, and a short C-terminal cytoplasmic domain that interacts with adaptor molecules. The transcript is expressed at high levels in the brain, and candidate gene studies suggest that genetic variation in this gene is associated with Alzheimer's disease. Consistent with this observation, knockdown of the gene in cell culture results in an increase in amyloid precursor protein processing. [provided by RefSeq, Dec 2014]
Gene Name: Sortilin Related VPS10 Domain Containing Receptor 3
Chromosome: CHR10: 106400858 -107024993
Locus: 10q25.1
ARHGAP12 Gene Summary
This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may be involved in suppressing tumor formation by regulating cell invasion and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Gene Name: Rho GTPase Activating Protein 12
Chromosome: CHR10: 32095224 -32217770
Locus: 10p11.22
Gene Diseases
The ARHGAP12 SORCS3 Fusion has been associated with the following diseases:
| Disease Name |
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| Head And Neck Squamous Cell Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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