ARHGAP12-SVIL Fusion FISH Probe
The ARHGAP12-SVIL Fusion FISH Probe is used to confirm a fusion of the ARHGAP12 and SVIL genes. The fusion of the ARHGAP12 and SVIL genes has been associated with Prostate Adenocarcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ARHGAP12-SVIL-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ARHGAP12-SVIL-20-RERE | 20 (40 μL) | 200 μL |
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| ARHGAP12-SVIL-20-REOR | 20 (40 μL) | 200 μL |
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| ARHGAP12-SVIL-20-REGO | 20 (40 μL) | 200 μL |
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| ARHGAP12-SVIL-20-REGR | 20 (40 μL) | 200 μL |
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| ARHGAP12-SVIL-20-REAQ | 20 (40 μL) | 200 μL |
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| ARHGAP12-SVIL-20-ORRE | 20 (40 μL) | 200 μL |
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| ARHGAP12-SVIL-20-OROR | 20 (40 μL) | 200 μL |
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| ARHGAP12-SVIL-20-ORGO | 20 (40 μL) | 200 μL |
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| ARHGAP12-SVIL-20-ORAQ | 20 (40 μL) | 200 μL |
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| ARHGAP12-SVIL-20-GORE | 20 (40 μL) | 200 μL |
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| ARHGAP12-SVIL-20-GOOR | 20 (40 μL) | 200 μL |
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| ARHGAP12-SVIL-20-GOGO | 20 (40 μL) | 200 μL |
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| ARHGAP12-SVIL-20-GOGR | 20 (40 μL) | 200 μL |
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| ARHGAP12-SVIL-20-GOAQ | 20 (40 μL) | 200 μL |
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| ARHGAP12-SVIL-20-GRRE | 20 (40 μL) | 200 μL |
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| ARHGAP12-SVIL-20-GROR | 20 (40 μL) | 200 μL |
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| ARHGAP12-SVIL-20-GRGO | 20 (40 μL) | 200 μL |
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| ARHGAP12-SVIL-20-GRGR | 20 (40 μL) | 200 μL |
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| ARHGAP12-SVIL-20-GRAQ | 20 (40 μL) | 200 μL |
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| ARHGAP12-SVIL-20-AQRE | 20 (40 μL) | 200 μL |
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| ARHGAP12-SVIL-20-AQOR | 20 (40 μL) | 200 μL |
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| ARHGAP12-SVIL-20-AQGO | 20 (40 μL) | 200 μL |
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| ARHGAP12-SVIL-20-AQGR | 20 (40 μL) | 200 μL |
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| ARHGAP12-SVIL-20-AQAQ | 20 (40 μL) | 200 μL |
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SVIL Gene Summary
This gene encodes a bipartite protein with distinct amino- and carboxy-terminal domains. The amino-terminus contains nuclear localization signals and the carboxy-terminus contains numerous consecutive sequences with extensive similarity to proteins in the gelsolin family of actin-binding proteins, which cap, nucleate, and/or sever actin filaments. The gene product is tightly associated with both actin filaments and plasma membranes, suggesting a role as a high-affinity link between the actin cytoskeleton and the membrane. The encoded protein appears to aid in both myosin II assembly during cell spreading and disassembly of focal adhesions. Several transcript variants encoding different isoforms of supervillin have been described. [provided by RefSeq, Apr 2016]
Gene Name: Supervillin
Chromosome: CHR10: 29746276 -30024730
Locus: 10p11.23
ARHGAP12 Gene Summary
This gene encodes a member of a large family of proteins that activate Rho-type guanosine triphosphate (GTP) metabolizing enzymes. The encoded protein may be involved in suppressing tumor formation by regulating cell invasion and adhesion. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Gene Name: Rho GTPase Activating Protein 12
Chromosome: CHR10: 32095224 -32217770
Locus: 10p11.22
Gene Diseases
The ARHGAP12 SVIL Fusion has been associated with the following diseases:
| Disease Name |
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| Prostate Adenocarcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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