ARHGAP42-PGR Fusion FISH Probe
The ARHGAP42-PGR Fusion FISH Probe is used to confirm a fusion of the ARHGAP42 and PGR genes. The fusion of the ARHGAP42 and PGR genes has been associated with Breast Invasive Carcinoma. These probes are FISH confirmed on normal peripheral blood in both interphase nuclei and metaphase spreads before shipment. Typical turnaround time for this product is 7-14 days after purchase.
** This product is for in vitro and research use only. This product is not intended for diagnostic use. Please note that both genes fall on the same chromosome and inter-chromosomal detection may be difficult to detect depending on the genes proximity to one another. Please consult our support staff before ordering this product to ensure that the probe can be designed to meet your specific needs.
| SKU | Test Kits | Buffer | Dye Color | Order Now |
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| ARHGAP42-PGR-20-ORGR (Standard Design) | 20 (40 μL) | 200 μL |
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| ARHGAP42-PGR-20-RERE | 20 (40 μL) | 200 μL |
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| ARHGAP42-PGR-20-REOR | 20 (40 μL) | 200 μL |
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| ARHGAP42-PGR-20-REGO | 20 (40 μL) | 200 μL |
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| ARHGAP42-PGR-20-REGR | 20 (40 μL) | 200 μL |
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| ARHGAP42-PGR-20-REAQ | 20 (40 μL) | 200 μL |
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| ARHGAP42-PGR-20-ORRE | 20 (40 μL) | 200 μL |
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| ARHGAP42-PGR-20-OROR | 20 (40 μL) | 200 μL |
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| ARHGAP42-PGR-20-ORGO | 20 (40 μL) | 200 μL |
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| ARHGAP42-PGR-20-ORAQ | 20 (40 μL) | 200 μL |
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| ARHGAP42-PGR-20-GORE | 20 (40 μL) | 200 μL |
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| ARHGAP42-PGR-20-GOOR | 20 (40 μL) | 200 μL |
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| ARHGAP42-PGR-20-GOGO | 20 (40 μL) | 200 μL |
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| ARHGAP42-PGR-20-GOGR | 20 (40 μL) | 200 μL |
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| ARHGAP42-PGR-20-GOAQ | 20 (40 μL) | 200 μL |
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| ARHGAP42-PGR-20-GRRE | 20 (40 μL) | 200 μL |
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| ARHGAP42-PGR-20-GROR | 20 (40 μL) | 200 μL |
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| ARHGAP42-PGR-20-GRGO | 20 (40 μL) | 200 μL |
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| ARHGAP42-PGR-20-GRGR | 20 (40 μL) | 200 μL |
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| ARHGAP42-PGR-20-GRAQ | 20 (40 μL) | 200 μL |
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| ARHGAP42-PGR-20-AQRE | 20 (40 μL) | 200 μL |
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| ARHGAP42-PGR-20-AQOR | 20 (40 μL) | 200 μL |
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| ARHGAP42-PGR-20-AQGO | 20 (40 μL) | 200 μL |
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| ARHGAP42-PGR-20-AQGR | 20 (40 μL) | 200 μL |
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| ARHGAP42-PGR-20-AQAQ | 20 (40 μL) | 200 μL |
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PGR Gene Summary
This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Sep 2015]
Gene Name: Progesterone Receptor
Chromosome: CHR11: 100900354 -101000544
Locus: 11q22.1
ARHGAP42 Gene Summary
This gene encodes a Rho GTPase-activating protein (RhoGAP), and member of the GRAF or BAR-PH family of proteins. Expression of this gene is enriched in vascular smooth muscle cells and the encoded protein inhibits RhoA activity to regulate vascular tone and control blood pressure. A mutation in the first intron of this gene modulates its expression and is associated with reduced blood pressure in human patients with borderline hypertension. [provided by RefSeq, Jul 2017]
Gene Name: Rho GTPase Activating Protein 42
Chromosome: CHR11: 100558406 -100861656
Locus: 11q22.1
Gene Diseases
The ARHGAP42 PGR Fusion has been associated with the following diseases:
| Disease Name |
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| Breast Invasive Carcinoma |
FISH Probe Protocols
| Protocol, Procedure, or Form Name | Last Modified | Download |
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